信号通路, 信号转导, Cell Signaling

别名：CGI1746；4-(tert-butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morpholine-4-carbonyl)phenyl)amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)benzamide；4-(叔丁基)-N-(2-甲基-3-(4-甲基-6-((4-(吗啉-4-羰基)苯基)氨基)-5-氧代-4,5-二氢吡嗪-2-基)苯基)苯甲酰胺

CAS：910232-84-7；分子式：C34H37N5O4；分子量：579.69

别名： GW 2580；GW-2580；5-[[3-甲氧基-4-[(4-甲氧基苯基)甲氧基]苯基]甲基]-2,4-甲苯酚二胺；5-[[3-甲氧基-4-[(4-甲氧基苯基)甲氧基]苯基]甲基]熔融吡啶-2,4-二胺；5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-Pyrimidinediamine, 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine

Empirical Formula (Hill Notation): C20H22N4O3 CAS号: 870483-87-7 分子量: 366.41 NACRES: NA.77

别名：福替尼；N-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide；N-(3-氟-4-((-甲氧基-7-(3-吗啉代丙氧基)喹啉-4-基)氧基)苯基)-N-(4-氟苯基)环丙烷-1,1-二甲酰胺

CAS：849217-64-7；分子式：C34H34F2N4O6；分子量：632.65；MDL：MFCD16038048

别名：双马来酸盐阿法替尼；Afatinib (dimaleate)；(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide dimaleate

Empirical Formula (Hill Notation): C32H33ClFN5O11 CAS号: 850140-73-7 分子量: 718.08 MDL编号: MFCD25974239

别名：(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide dimaleate BIBW2992 (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide dimaleate；(S)-N-(4-((3-氯-4-氟苯基)胺)-7-((四氢呋喃-3-基)氧基)喹唑啉-6-基)-4-(二甲氨基)丁-2-烯胺

CAS：439081-18-2；分子式：C24H25ClFN5O3；分子量：485.94

别名：Tucatinib；ONT 380；N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)quinazoline-4,6-diamine

CAS：937263-43-9；分子式：C26H24N8O2；分子量：480.53

别名：HM 61713；BI1482694；N-(3-((2-((4-(4-甲基哌嗪-1-基)苯基)氨基)噻吩并[3,2-d]嘧啶-4-基)氧基)苯基)丙烯酰胺；N-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}thieno[3,2-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide

CAS：1353550-13-6；分子式：C26H26N6O2S；分子量：486.59

别名：酪磷蛋白AG490；酪氨酸磷酸化抑制剂AG 490；2-氰基-3-(3,4-二羟基苯基)-N-(苄基)-2-丙烯酰胺, 2-氰基-3-(3,4-二羟基苯基)-N-(苯甲基)-2-丙烯酰胺；2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide

Empirical Formula (Hill Notation): C17H14N2O3 CAS号: 133550-30-8 分子量: 294.30 MDL编号: MFCD00236452 PubChem化学物质编号: 24278732 NACRES: NA.77

别名：VS-6063；PF-04554878；N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide

CAS：1345713-71-4；分子式：C20H21F3N8O3S；分子量：510.49

别名：N-甲基-N-(2-(((2-((2-氧代二氢吲哚-5-基)氨基)-5-(三氟甲基)嘧啶-4-基)氨基)甲基)苯基)甲磺酰胺；N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-Methanesulfonamide hydrate

Empirical Formula (Hill Notation): C22H21F3N6O3S · xH2O CAS号: 717906-29-1 分子量: 506.50 (anhydrous basis) MDL编号: MFCD21608515 PubChem化学物质编号: 329823759 NACRES: NA.77

别名：FGFR抑制剂；FIIN2；FIIN 2；N-(4-(3,5-二甲氧基苯基)-7-(4-(4-甲基哌嗪-1-基)苯基)氨基)-2-氧代-3,4-二氢嘧啶并[4,5-d]嘧啶-1(2H)-甲基)苯基)丙烯酰胺；N-(4-((3-(3,5-dimethoxyphenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide

CAS：1633044-56-0；分子式：C35H38N8O4；分子量：634.73

别名：3-(2,6-二氯-3,5-二甲氧基苯基)-1-[6-[[4-(4-乙基哌嗪-1-基)苯基]氨基]嘧啶-4-基]-1-甲基脲；3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-[6-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]-1-methylurea

CAS：872511-34-7；分子式：C26H31Cl2N7O3；分子量：560.47；MDL：MFCD22123241