妥卡替尼，Irbinitinib [ARRY-380]；≥99% (HPLC)

General description

一种具有口服活性的ErbB-2（表皮生长因子受体）抑制剂，具有潜在的抗肿瘤活性。

Irbinitinib is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation。

Irbinitinib是人类表皮生长因子受体酪氨酸激酶ErbB-2（也称为HER2）的口服生物利用抑制剂，具有潜在的抗肿瘤活性。 ErbB-2抑制剂ARRY-380选择性结合并抑制ErbB-2的磷酸化，这可能阻止ErbB-2信号转导途径的激活，从而导致生长抑制和表达ErbB-2的肿瘤细胞死亡。 ErbB-2在多种癌症中过表达，在细胞增殖和分化中起着重要作用。

安全信息