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奥莫替尼 ,Olmutinib;≥99% (HPLC)

别名:HM 61713;BI1482694;N-(3-((2-((4-(4-甲基哌嗪-1-基)苯基)氨基)噻吩并[3,2-d]嘧啶-4-基)氧基)苯基)丙烯酰胺;N-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}thieno[3,2-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide

CAS:1353550-13-6;分子式:C26H26N6O2S;分子量:486.59
制造商品牌: BSZH 科学公司
货号(SKU): S06228
CAS号: 1353550-13-6
MDL号: MFCD29918158
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¥926.00

产品描述

本品可溶于DMSO(97mg/mL)

General description

一种BTK抑制剂。
Olmutinib is a potent small molecule inhibitor of Bruton's tyrosine kinase (BTK). BTK is a member of the Tec family of non-receptor protein tyrosine kinases. BTK is mostly expressed in hematopoietic cells such as B cells, mast cells and macrophages. BTK plays key roles in multiple cell signaling pathways including B-Cell Receptor (BCR) and Fc receptor (FcR) signaling cascades and is an essential mediator not only in B-cell dependent but also in myeloid cell dependent inflammatory arthritis. HM71224 has been selected as a novel therapeutic agent for the treatment of autoimmune diseases such as RA。

Olmutinib是Bruton酪氨酸激酶(BTK)的有效小分子抑制剂。 BTK是非受体蛋白酪氨酸激酶Tec家族的成员。 BTK主要在造血细胞如B细胞,肥大细胞和巨噬细胞中表达。 BTK在包括B细胞受体(BCR)和Fc受体(FcR)信号级联在内的多种细胞信号通路中起着关键作用,不仅在依赖B细胞而且在依赖髓样细胞的炎性关节炎中也是必不可少的介质。 HM71224已被选为治疗自身免疫性疾病(例如RA)的新型治疗剂。

Properties

Iupac NameN-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide
Inchi Code1S/C26H26N6O2S/c1-3-23(33)27-19-5-4-6-21(17-19)34-25-24-22(11-16-35-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30)
Inchi KeyFDMQDKQUTRLUBU-UHFFFAOYSA-N


安全信息

风险声明 (欧洲) 23/24/25
安全声明 (欧洲) 26-36
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10