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Defactinib,[VS-6063, PF-04554878];≥99% (HPLC)

别名:VS-6063;PF-04554878;N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide

CAS:1345713-71-4;分子式:C20H21F3N8O3S;分子量:510.49
制造商品牌: BSZH 科学公司
货号(SKU): D06230
CAS号: 1345713-71-4
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¥1,550.00

产品描述

本品可溶于DMSO(5 mg/mL 加热)

General description

一种口服有效的FAK(粘附斑激酶)抑制剂,具有潜在的抗血管生成和抗肿瘤活性。

Defactinib is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival。

Defactinib是一种口服生物利用的小分子粘着斑激酶(FAK)抑制剂,具有潜在的抗血管生成和抗肿瘤活性。 FAK抑制剂PF-04554878抑制FAK,可能阻止整联蛋白介导的多种下游信号转导通路的激活,包括ERK,JNK / MAPK和PI3K / Akt,从而抑制肿瘤细胞的迁移,增殖和存活。

IUPAC/Chemical Name: N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide

InChi Key: FWLMVFUGMHIOAA-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30)

SMILES Code: O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(=O)(C)=O)=N2)C=C1

Appearance: white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water


安全信息

风险声明 (欧洲) 23/24/25
安全声明 (欧洲) 26-36
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16