Dimebon dihydrochloride hydrate；≥98% (HPLC)

图片 Dimebon dihydrochloride hydrate；≥98% (HPLC)
别名：拉曲吡啶二盐酸盐；Latrepirdine 2HCl；盐酸地美邦水合物；2,3,4,5-四氢-2,8-二甲基-5-[2-(6-甲基-3-吡啶基)乙基]-1H-吡啶并[4,3-B]吲哚二盐酸盐；Dimebone dihydrochloride hydrate, Dimeboline dihydrochloride hydrate, Dimebolin dihydrochloride hydrate, 2,8-Dimethyl-5-2-(6-methyl-3-pyridinyl)ethyl-2,3,4,5-tetrahydro-1H-pyrido4,3-bindole dihydrochloride hydrate

Empirical Formula (Hill Notation): C21H25N3 · 2HCl · xH2O CAS号: 97657-92-6 (anhydrous) 分子量: 392.37 (anhydrous basis) MDL编号: MFCD17215933 PubChem化学物质编号: 329798824 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: D6196
CAS号: 97657-92-6
MDL号: MFCD17215933
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说明

生化/生理作用

Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.
 

特点和优势

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

测定

≥98% (HPLC)

形式

powder

颜色

white to off-white

溶解性

H2O: ≥10 mg/mL

创始人

Pfizer

储存温度

2-8°C

SMILES string

O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4

InChI

1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2

InChI key

QQHQMWVYYVVAOV-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302 - H315 - H319

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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