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Dimebon dihydrochloride hydrate,≥98% (HPLC)

别名:Dimebon二盐酸盐水合物;Dimebone dihydrochloride hydrate, Dimeboline dihydrochloride hydrate, Dimebolin dihydrochloride hydrate, 2,8-Dimethyl-5-2-(6-methyl-3-pyridinyl)ethyl-2,3,4,5-tetrahydro-1H-pyrido4,3-bindole dihydrochloride hydrate

Empirical Formula (Hill Notation): C21H25N3 · 2HCl · xH2O CAS号: 97657-92-6 (anhydrous) 分子量: 392.37 (anhydrous basis) MDL编号: MFCD17215933 PubChem化学物质编号: 329798824 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): D6196
CAS号: 97657-92-6
MDL号: MFCD17215933
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$287.09

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.
神经保护和认知增强的机制尚不确定,但 Dimebon 同时阻断胆碱酯酶和 NMDA 受体,也似乎阻断神经毒性 β-淀粉样蛋白的作用和抑制 L 型钙通道,并可能通过阻断 涉及线粒体孔的新靶点。
 

特点和优势

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
 

属性

测定

≥98% (HPLC)

形式

powder

颜色

white to off-white

溶解性

H2O: ≥10 mg/mL

创始人

Pfizer

储存温度

2-8°C

SMILES string

O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4

InChI

1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2

InChI key

QQHQMWVYYVVAOV-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

危害代码

Xn

风险声明

22-36/38

安全声明

26-36/39

RIDADR

NONH for all modes of transport

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16