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PD-166866,≥98% (HPLC)

别名:PD166866;PD 166866;1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea;1-(2-氨基-6-(3,5-二甲氧基苯基)吡啶并[2,3-d]嘧啶-7-基)-3-(叔丁基)脲

CAS号 192705-79-6 经验分子式(希尔表示法) C20H24N6O3 分子量 396.44 MDL number MFCD12922514 PubChem Substance ID 329823706 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0114
CAS号: 192705-79-6
MDL号: MFCD12922514
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¥1,307.07

产品描述

一种FGF-1受体酪氨酸激酶(FGFR1)的选择性抑制剂,IC50:55 nM

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.

This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

法律信息

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Pfizer is a registered trademark of Pfizer, Inc.

性质

Quality Level  100
assay  ≥98% (HPLC)
mfr. no.  Pfizer®
color  off-white to light tan
solubility  DMSO: ≥10 mg/mL
originator  Pfizer
storage temp.  2-8°C
SMILES string  COc1cc(OC)cc(c1)-c2cc3cnc(N)nc3nc2NC(=O)NC(C)(C)C
InChI  1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
InChI key  NHJSWORVNIOXIT-UHFFFAOYSA-N


安全信息

危害码 (欧洲) Xn
风险声明 (欧洲) 22
RIDADR NONH for all modes of transport
WGK德国 WGK 1
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10