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OF-1,≥98% (HPLC)

别名:4-溴-N-(2,3-二氢-6-甲氧基-1,3-二甲基-2-氧代-1H-苯并咪唑-5-基)-2-甲基-苯磺酰胺;4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide

Empirical Formula (Hill Notation): C17H18BrN3O4S CAS号: 919973-83-4 分子量: 440.31 MDL编号: MFCD26964046 PubChem化学物质编号: 329825706 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1184
CAS号: 919973-83-4
MDL号: MFCD26964046
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$292.50

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) that assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. OF-1 binds to BRPF1B with a Kd of 100 nM , to BRPF2 with a Kd of 500 nM and to BRPF3 with a Kd of 2.4 mM, and shows >100-fold selectivity against most other bromodomains. The closest off-target effects are against BRD4 (39-fold selectivity) and 50% inhibition of TIF1a at 20 μM. For full characterization details, please see OF-1 on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
 
OF-1 是用于组装 MYST 家族成员 MOZ 和 MORF 的组蛋白乙酰转移酶 (HAT) 复合物的支架蛋白(BRPF1、BRPF2、BRPF3)家族的 BRPF(包含 BRomodomain 和 PHD Finger)溴结构域的化学探针。 BRPF1 蛋白是 MYST 乙酰转移酶复合物的支架亚基,在 DNA 修复、重组和复制以及转录激活中起着至关重要的作用。 OF-1 结合 BRPF1B 的 Kd 为 100 nM,结合 BRPF2 的 Kd 为 500 nM,结合 BRPF3 的 Kd 为 2.4 mM,并且对大多数其他溴结构域的选择性超过 100 倍。
 

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
OF-1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES string

BrC1=CC(C)=C(S(NC(C(OC)=C2)=CC(N3C)=C2N(C)C3=O)(=O)=O)C=C1

InChI

1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3

InChI key

YUNQZQREIHWDQT-UHFFFAOYSA-N

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16