SC-26196，≥98% (HPLC)

图片 SC-26196，≥98% (HPLC)
别名：2,2-二苯基-5-(4-((吡啶-3-基亚甲基)氨基)哌嗪-1-基)戊腈；a,a-二苯基-4-[(3-吡啶基亚甲基)氨基]-1-哌嗪基戊腈；SC-26196；a,a-diphenyl-4-(3-pyridinylmethylene)amino-1-piperazinepentanenitrile; 2,2-diphenyl-5-(4-(1 E)-pyridin-3-yl-methylideneaminopiperazin-1-yl)pentanenitrile

Empirical Formula (Hill Notation): C27H29N5 分子量: 423.55 MDL编号: MFCD11226148 PubChem化学物质编号: 329823750 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0176
CAS号: 218136-59-5
MDL号: MFCD11226148
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说明

应用

SC-26196 has been used as an inhibitor of delta6 (Δ6) fatty acid desaturase:
  • in mouse inner medullary collecting duct (IMCD3) and human (female) embryonic kidney (HEK) 293 cell culture as Dulbecco′s modified eagle′s medium (DMEM) component[1]
  • in hepatic HepG2 cells[2]
  • in glioblastoma cell lines to test its effect post-radiation treatments[3]

生化/生理作用

SC-26196 is a Delta6 fatty acid desaturase (Delta6D) inhibitor. It specifically inhibited Delta6D activity with an IC(50) value of 100 nM. The rate-limiting step in arachidonic acid synthesis is the desaturation of dietary linoleic acid by Delta6D. SC-26196 completely prevented this conversion of linoleic acid to arachidonic acid.
 

其他说明

This compound was developed by Pfizer for Lipid Signaling research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to tan

溶解性

DMSO: ≥10 mg/mL

创始人

Pfizer

储存温度

2-8°C

SMILES string

N#CC(CCCN1CCN(CC1)\N=C\c2cccnc2)(c3ccccc3)c4ccccc4

InChI

1S/C27H29N5/c28-23-27(25-10-3-1-4-11-25,26-12-5-2-6-13-26)14-8-16-31-17-19-32(20-18-31)30-22-24-9-7-15-29-21-24/h1-7,9-13,15,21-22H,8,14,16-20H2/b30-22+

InChI key

QFYKXKMYVYOUNJ-JBASAIQMSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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