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T0901317,≥98%

别名:N-(4-(1,1,1,3,3,3-六氟-2-羟基丙-2-基)苯基)-N-(2,2,2-三氟乙基)苯磺酰胺;N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2, 2-trifluoroethyl)benzenesulfonamide; N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide

CAS号 293754-55-9 经验分子式(希尔表示法) C17H12NSO3F9 分子量 481.33 MDL number MFCD03412028 PubChem Substance ID 24900032 NACRES NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): T2320
CAS号: 293754-55-9
MDL号: MFCD03412028
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¥848.00

产品描述

一种有效的选择性的LXR和FXR激动剂.EC50分别是50 nM和5 μM.

Application

T0901317 has been used in LXR agonist study[3] in order to observe the expression of all dietary cholesterol-regulated genes in mice.[2] It has also been used to stimulate the radiolabeled peritoneal macrophages from WT (wildtype) and Tg (transgenic) mice for cellular cholesterol efflux assay.[4]

T0901317已用于LXR激动剂研究[3],以观察所有饮食中胆固醇调节的基因在小鼠中的表达。[2] 它也已用于刺激野生型和Tg(转基因)小鼠的放射性标记的腹膜巨噬细胞,以进行细胞胆固醇外排测定。[4]

Biochem/physiol Actions

T0901317 can prevent the secretion of insulin by acting on the metabolism of mitochondria.[1]

LXR激动剂,其治疗导致ABC1基因表达的LXR依赖性上调

性质

Quality Level  200
assay  ≥98%
mol wt  481.3
storage temp.  −20°C
SMILES string  OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F
InChI  1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
InChI key  SGIWFELWJPNFDH-UHFFFAOYSA-N
Gene Information  human ... ABCA1(19), NR1H2(7376), NR1H3(10062)


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32