sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

PF-6274484,≥98% (HPLC)

别名:PF6274484;N-[4-[(3-氯-4-氟苯基)氨基]-7-甲氧基-6-喹唑啉基]-2-丙烯酰胺;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide

Empirical Formula (Hill Notation): C18H14ClFN4O2 CAS号: 1035638-91-5 分子量: 372.78 MDL编号: MFCD30182370 PubChem化学物质编号: 329823851
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0342
CAS号: 1035638-91-5
MDL号: MFCD30182370
增值税发票 √ 免费送货 √ 订货电话:010-68689484
€228.53

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.
 
PF-6274484 是一种不可逆的 EGFR 激酶抑制剂,可与 ATP 结合口袋中的活性位点半胱氨酸残基发生共价反应。 PF-6274484 抑制肿瘤细胞中野生型和突变型 EGFR 的自磷酸化,IC50 值分别为 5.8 nM 和 6.6 nM。
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to light brown

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OC)=C(NC(C=C)=O)C=C32

InChI

1S/C19H16ClFN4O/c1-4-11(2)24-17-8-13-16(9-18(17)26-3)22-10-23-19(13)25-12-5-6-15(21)14(20)7-12/h4-10,24H,1-2H2,3H3,(H,22,23,25)

InChI key

DTMQCGFVWWBONL-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16