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ST034307,≥98% (HPLC)

别名:6-氯-2-(三氯甲基)-4H-苯并吡喃-4-酮;6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one, 6-Chloro-2-(trichloromethyl)chromen-4-one

CAS号 133406-29-8 经验分子式(希尔表示法) C10H4Cl4O2 分子量 297.95 MDL number MFCD00760793 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML2109
CAS号: 133406-29-8
MDL号: MFCD00760793
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¥1,066.22

产品描述

一种具有镇痛活性的腺苷酸环化酶1(AC1)的选择性抑制剂,IC50:2.3 μM。

Biochem/physiol Actions

ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity. Adenylyl cyclase 1 has been shown to be a potential target for treating pain and reducing the dependency on opioids, but it has been difficult to inhibit AC1 selectively without also inhibiting other isoforms vital to physiological functions. ST034307 is selective for AC1 over all eight other adenylyl cyclase isoforms. It inhibited AC1 and reduced cAMP, while leaving AC8 unaffected and was shown to reduce pain in a mouse inflammatory pain model.

ST034307是具有镇痛活性的腺苷酸环化酶1(AC1)的选择性抑制剂。 腺苷酸环化酶1已被证明是治疗疼痛和减少对阿片类药物依赖性的潜在靶标,但是很难选择性地抑制AC1而又不抑制其他对生理功能至关重要的亚型。 ST034307对所有其他八种腺苷酸环化酶同工型均具有AC1选择性。 它抑制AC1并降低cAMP,而使AC8不受影响,并在小鼠炎症性疼痛模型中显示出减轻疼痛的作用。

性质

assay  ≥98% (HPLC)
form  powder
color  faint green to dark gray
solubility  DMSO: 2 mg/mL, clear (warmed)
storage temp.  −20°C
SMILES string  ClC(Cl)(Cl)C1=CC(C2=CC(Cl)=CC=C2O1)=O


安全信息

RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32