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OTX015 [MK-8628, Birabresib];≥98% (HPLC)

别名:(S)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂卓-6-基)-N-(4-羟基苯基)乙酰胺;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6S)-, OTX-015

CAS号 202590-98-5 经验分子式(希尔表示法) C25H22ClN5O2S 分子量 491.99 MDL number MFCD26960949 PubChem Substance ID 329825491 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1605
CAS号: 202590-98-5
MDL号: MFCD26960949
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¥2,643.76

产品描述

一种有效的BET bromodomain抑制剂,靶向BRD2/3/4,EC50范围为10nM到19nM。

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

It binds to bromodomain and extra-terminal domain (BET) proteins and inhibits their binding to the chromatin. This in turn prevents gene transcription. OTX015 has been shown to inhibit proliferation of cells in haematological malignancies.[1]

OTX015 is a potent inhibitor of the BET bromodomain proteins 2, 3, and 4 (BRD2/3/4).

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to light brown
solubility  DMSO: 20 mg/mL, clear
storage temp.  2-8°C
SMILES string  O=C(NC(C=C1)=CC=C1O)C[C@H]2C3=NN=C(C)N3C(SC(C)=C4C)=C4C(C5=CC=C(Cl)C=C5)=N2
InChI  1S/C25H22ClN5O2S/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)28-20(24-30-29-15(3)31(24)25)12-21(33)27-18-8-10-19(32)11-9-18/h4-11,20,32H,12H2,1-3H3,(H,27,33)/t20-/m0/s1
InChI key  GNMUEVRJHCWKTO-FQEVSTJZSA-N
Gene Information  human ... BRD2(6046), BRD3(8019), BRD4(23476), BRDT(676)


安全信息

RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16