PF-03084014 hydrobromide，≥98% (HPLC)

图片 PF-03084014 hydrobromide，≥98% (HPLC)
别名：(2S)-2-(2S)-6,8-二氟-1,2,3,4-四氢-2-萘基]氨基]-N-[1-[2-[（2,2-二甲基丙基）氨基]-1,1-二甲基乙基]-1H-咪唑-4-基]戊酰胺氢溴酸盐；(2S)-2-(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenylamino-N-1-2-(2,2-dimethylpropyl)amino-1,1-dimethylethyl-1H-imidazol-4-yl-pentanamide hydrobromide, PF 3084014 hydrobromide, Nirogacestat, PF 03084014 hydrobromide, PF-3084014 hydrobromide

Empirical Formula (Hill Notation): C27H41F2N5O · HBr CAS号: 1290543-63-3 (free base) 分子量: 570.56 PubChem化学物质编号: 329823821 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0298
CAS号: 1290543-63-3
MDL号: MFCD19980705
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¥1,364.05

说明

生化/生理作用

PF-03084014 inhibits the Notch signalling pathway.[1] It contributes totumor suppression in breast, pancreatic carcinoma,[1] hepatocellular carcinoma[2] and progressive desmoid tumors.[3] PF-03084014 in combination with dexamethasone elicits antileukemic effects in T-cell acute lymphoblastic leukemias (T-ALL).[4]
PF-03084014 is a highly potent γ-secretase inhibitor that reduces Aβ production in vitro. PF-03084014 does not show a paradoxical increase in plasma Aβ at low concentrations in both preclinical species and humans.
 

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

H2O: 1 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

FC1=C2C(CCC@H(NC@@H(CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1.C

InChI

1S/C27H41F2N5O.CH4/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4;/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35);1H4/t20-,23-;/m0./s1

InChI key

GLEYBLZDOTUZJH-WCRWPNQISA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
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