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OSU6162 hydrochloride,≥98% (HPLC)

别名:PNU-96391; PNU-0096391; OSU-6162; (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine hydrochloride; (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride

Empirical Formula (Hill Notation): C15H23NO2S·HCl CAS号: 156907-84-5 分子量: 317.87 MDL编号: MFCD09753276 PubChem化学物质编号: 329823751 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0177
CAS号: 156907-84-5
MDL号: MFCD09753276
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$415.69

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

OSU6162 (PNU-96391) is a dopamine stabilizer, a drug that can stimulate or inhibit dopaminergic signaling depending on the dopaminergic tone. Dopaminergic stabilizers have been proposed to act as partial dopamine receptor agonists or as antagonists with both dopamine and behavioral stabilizing activity. Although affinity is not high (in vitro binding affinity for dopamine D2 receptor has a Ki of 447 nM), OSU6162 shows a high level of receptor occupancy.
 
OSU6162 (PNU-96391) 是一种多巴胺稳定剂,一种可以根据多巴胺能基调刺激或抑制多巴胺能信号传导的药物。 已提出多巴胺能稳定剂作为部分多巴胺受体激动剂或同时具有多巴胺和行为稳定活性的拮抗剂。 尽管亲和力不高(对多巴胺 D2 受体的体外结合亲和力的 Ki 为 447 nM),但 OSU6162 显示出高水平的受体占有率。
 

特点和优势

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.
 

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

旋光性

[α]/D -5 to -7°, c = 1 in methanol

mfr. no.

Pfizer®

颜色

white to tan

溶解性

H2O: ≥16 mg/mL

创始人

Pfizer

储存温度

−20°C

SMILES string

Cl.CCCN1CCC[C@H](C1)c2cccc(c2)S(C)(=O)=O

InChI

1S/C15H23NO2S.ClH/c1-3-9-16-10-5-7-14(12-16)13-6-4-8-15(11-13)19(2,17)18;/h4,6,8,11,14H,3,5,7,9-10,12H2,1-2H3;1H/t14-;/m1./s1

InChI key

LEMGVHZVBREXAD-PFEQFJNWSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16