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BAY-6035,≥98% (HPLC)

别名:BAY6035, BAY 6035, (2S)-1-(3-Azabicyclo[3.1.0]hexane-3-carbonyl)-N-(2-cyclopropylethyl)-2-methyl-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-carboxamide;(2S)-1-(3-氮杂双环[3.1.0]己烷-3-羰基)-N-(2-环丙基乙基)-2-甲基-4-氧代-2,3,4,5-四氢-1H- 苯并[b][1,4]二氮杂-7-甲酰胺

Empirical Formula (Hill Notation): C22H28N4O3 分子量: 396.48 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML2325
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$340.36

说明

生化/生理作用

BAY-6035 is a substrate-competitive, potent and selective SMYD3 inhibitor (IC50 = 88 nM by cell-free MEKK2 peptide methylation; IC50 = 70 nM against cellular MEKK2 methylation) with >100-fold selectivity over other histone methyltransferases. BAY-211 is a structural analog and the recommended inactive control (IC50 = 23 μM by cell-free MEKK2 peptide methylation) for BAY-6035. For characterization details of BAY-6035, please visit the BAY-6035 probe summary on the Structural Genomics Consortium (SGC) website.

BAY-444 is the negative control for the active probe, BAY-6035. To request a sample of the negative control from the SGC, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
 
BAY-6035 是一种底物竞争性、有效和选择性 SMYD3 抑制剂(无细胞 MEKK2 肽甲基化的 IC50 = 88 nM;针对细胞 MEKK2 甲基化的 IC50 = 70 nM)比其他组蛋白甲基转移酶的选择性高 100 倍以上。 BAY-211 是一种结构类似物,是 BAY-6035 推荐的无活性对照(IC50 = 23 μM,无细胞 MEKK2 肽甲基化)。
 

特点和优势

BAY-6035 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
 

属性

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

−20°C

SMILES string

O=C1C[C@H](C)N(C(N2CC(C3)C3C2)=O)C4=CC=C(C(NCCC5CC5)=O)C=C4N1

 

安全信息

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16