BAY-6035，≥98% (HPLC)

BAY-6035 is a substrate-competitive, potent and selective SMYD3 inhibitor (IC50 = 88 nM by cell-free MEKK2 peptide methylation; IC50 = 70 nM against cellular MEKK2 methylation) with >100-fold selectivity over other histone methyltransferases. BAY-211 is a structural analog and the recommended inactive control (IC50 = 23 μM by cell-free MEKK2 peptide methylation) for BAY-6035. For characterization details of BAY-6035, please visit the BAY-6035 probe summary on the Structural Genomics Consortium (SGC) website.

BAY-444 is the negative control for the active probe, BAY-6035. To request a sample of the negative control from the SGC, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

 

BAY-6035 是一种底物竞争性、有效和选择性 SMYD3 抑制剂（无细胞 MEKK2 肽甲基化的 IC50 = 88 nM；针对细胞 MEKK2 甲基化的 IC50 = 70 nM）比其他组蛋白甲基转移酶的选择性高 100 倍以上。 BAY-211 是一种结构类似物，是 BAY-6035 推荐的无活性对照（IC50 = 23 μM，无细胞 MEKK2 肽甲基化）。

 

BAY-6035 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.