BAY-6035 is a substrate-competitive, potent and selective SMYD3 inhibitor (IC50 = 88 nM by cell-free MEKK2 peptide methylation; IC50 = 70 nM against cellular MEKK2 methylation) with >100-fold selectivity over other histone methyltransferases. BAY-211 is a structural analog and the recommended inactive control (IC50 = 23 μM by cell-free MEKK2 peptide methylation) for BAY-6035. For characterization details of BAY-6035, please visit the
BAY-6035 probe summary on the Structural Genomics Consortium (SGC) website.
BAY-444 is the negative control for the active probe, BAY-6035. To request a sample of the negative control from the SGC,
click here.
To learn about other SGC chemical probes for epigenetic targets, visit
sigma.com/sgc