DC260126，≥98% (HPLC)

Biochem/physiol Actions

DC260126 is a FFA1 (GPR40) selective antagonist. In FFA1-expressing CHO cells, DC260126 blocks linoleic acid-induced Ca²⁺ elevation and ERK phosphorylation (IC₅₀ = 6028 μM), as well as palmitic acid potentiated glucose-stimulated insulin secretion. The compound DC260126 blocks MIN6 β cells from palmitic acid-induced ER stress and apoptosis.

DC260126是FFA1（GPR40）选择性拮抗剂。 在表达FFA1的CHO细胞中，DC260126阻止亚油酸诱导的Ca2 +升高和ERK磷酸化（IC50 = 6028μM），以及棕榈酸增强的葡萄糖刺激的胰岛素分泌。 化合物DC260126阻止MIN6β细胞免受棕榈酸诱导的ER应激和细胞凋亡。

性质

安全信息

符号 

  GHS07

信号词 Warning

危害声明 H315 - H319 - H335

警示性声明 P302 + P352 - P305 + P351 + P338

靶器官 Respiratory system

危害码 (欧洲) Xi

风险声明 (欧洲) 36/37/38

安全声明 (欧洲) 26

RIDADR NONH for all modes of transport

WGK德国 WGK 3