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红霉素，Erythromycin；Pharmaceutical Secondary Standard; Certified Reference Material

别名：红霉素标准品；E-Mycin；Erythrocin；红丝菌素；艾狄密斯；阿达霉素；福爱力；红丝霉素；威霉素；新红康；Ilotycin；Ermycin

Empirical Formula (Hill Notation): C37H67NO13 CAS号: 114-07-8 分子量: 733.93 Beilstein: 75279 EC 号: 204-040-1 MDL编号: MFCD00084654 PubChem化学物质编号: 329823069 NACRES: NA.24

制造商品牌: 西格玛 Sigma-Aldrich , 默克色谱科 Supelco

货号（SKU）: PHR1039

CAS号: 114-07-8

MDL号: MFCD00084654

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目录价.SKU-Variant

¥1,376.00

数量:

说明

红霉素是一种复杂的大环内酯类抗生素，具有抑菌活性。由于其对革兰氏阳性和少数革兰氏阴性菌株的潜在活性，它通常用于人类和兽医。
红霉素是一种抗生素，由某些红链霉菌菌株生长产生。本品主要由红霉素A和少量红霉素B和C组成，建议浓度为100 mg/L。浓度在50至200mg/L之间也被证明对控制细菌生长有效。红霉素已被用作胃动素受体激动剂，在体外阻断人气道中的呼吸糖缀合物分泌，并用于选择质粒治愈和重组乳酸乳球菌MG1363菌株。
红霉素可用作通过各种色谱技术测定药物制剂中分析物的药物参考标准。

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Erythromycin is a complex macrolide antibiotic drug that exhibits a bacteriostatic activity. It is generally employed in human and veterinary medicines owing to its potential activity against gram positive and a few gram negative strains.

应用

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

Erythromycin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用，特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。
抗菌谱：该产品可以抗革兰氏阴性和革兰氏阳性细菌。

注意

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

制备说明

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3047 in the slot below. This is an example certificate only and may not be the lot that you receive.

法律信息

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDES 34:2009 (AClass Cert AR-1470).

属性

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 794
traceable to Ph. Eur. E1305000
traceable to USP 1242000

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

-10 to -25°C

SMILES string

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

ULGZDMOVFRHVEP-RWJQBGPGSA-N

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格

属性名称	属性值
储存温度 Storage temp.	-20°C低温冷冻
全球实时库存 Availability √	美国St. Louis ≥ 33 \| 欧洲Eur. ≥ 27 \| 東京Tokyo ≥ 9 \| 香港与北京 ≥ 16

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