WAY 170523，≥98% (HPLC)

图片 WAY 170523，≥98% (HPLC)
别名：WAY170523；WAY-170523；N-[2-[4-[2-[羟氨基）羰基]-4，6-二甲基苯基]（苯甲基）氨基]磺酰基]苯氧基]乙基]-2-苯并呋喃甲酰胺；N-[2-[4-[[[2-[(Hydroxyamino)carbonyl]-4,6-dimethylphenyl](phenylmethyl)amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide

Empirical Formula (Hill Notation): C33H31N3O7S CAS号: 307002-73-9 分子量: 613.68 MDL编号: MFCD09753279 PubChem化学物质编号: 329823839 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0322
CAS号: 307002-73-9
MDL号: MFCD09753279
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¥1,591.58

说明

生化/生理作用

WAY 170523 is a potent and selective inhibitor of matrix metalloprotease MMP-13 (Collagenase-3), expressed in the skeleton during embryonic development, and sometimes highly overexpressed in human carcinomas and in chondrocytes and synovial cells in rheumatoid arthritis and osteoarthritis. Mutations in the MMP-13 gene has been shown to cause metaphyseal anadysplasia (MANDP). WAY 170523 has an IC50 of 17 nM for MMP-13 and showed >5800-, 56-, and >500-fold selectivity against MMP-1, MMP-9, and TACE (TNFα converting enzyme), respectively.
 

其他说明

This compound was developed by Pfizer for Cytoskeleton & Extracellular Matrix research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 25 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

O=S(N(CC1=CC=CC=C1)C2=C(C(NO)=O)C=C(C)C=C2C)(C3=CC=C(OCCNC(C4=CC5=C(C=CC=C5)O4)=O)C=C3)=O

InChI

1S/C33H31N3O7S/c1-22-18-23(2)31(28(19-22)32(37)35-39)36(21-24-8-4-3-5-9-24)44(40,41)27-14-12-26(13-15-27)42-17-16-34-33(38)30-20-25-10-6-7-11-29(25)43-30/h3-15,18-20,39H,16-17,21H2,1-2H3,(H,34,38)(H,35,37)

InChI key

FARMEEAGJWMFSZ-UHFFFAOYSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
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储存温度 Storage temp.常温阴凉避光
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