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IQ-1S,≥98% (HPLC)

别名:11H-茚并[1,2-b]喹喔啉-11-酮肟;11H-Indeno[1,2-b]quinoxalin-11-one oxime Sodium; IQ-1 sodium

CAS号 23146-22-7 (free acid) 经验分子式(希尔表示法) C15H8N3O · Na 分子量 269.23 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0605
CAS号: 23146-22-7
MDL号: MFCD00612483
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1.567,00 kr

产品描述

一种JNK激酶抑制剂。

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

IQ-1S is an inhibitor of JNK kinases, with a preference for JNK3. Kd values for IQ-3 binding to JNK 1, 2 and 3 binding are 390, 360 and 87 nM, respectively. The compound inhibits JNK phosphorylation and NFkB /AP-1 transcriptional activity in human monocytic cells at low mM concentrations, and inhibits CD4+ T-cell immune response in a murine delayed-type hypersensitivity (DTH) model.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to beige
solubility  DMSO: 2 mg/mL, clear (warmed)
storage temp.  2-8°C


安全信息

RIDADR NONH for all modes of transport
WGK德国 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32