IQ-1S，≥98% (HPLC)

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

IQ-1S is an inhibitor of JNK kinases, with a preference for JNK3. Kd values for IQ-3 binding to JNK 1, 2 and 3 binding are 390, 360 and 87 nM, respectively. The compound inhibits JNK phosphorylation and NFkB /AP-1 transcriptional activity in human monocytic cells at low mM concentrations, and inhibits CD4+ T-cell immune response in a murine delayed-type hypersensitivity (DTH) model.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

性质

安全信息