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BCTC,≥98% (HPLC)

别名:4-(3-氯-2-吡啶基)-N-[4-叔丁基苯基]-1-哌嗪甲酰胺;4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide

CAS号 393514-24-4 经验分子式(希尔表示法) C20H25ClN4O 分子量 372.89 MDL number MFCD08690556 PubChem Substance ID 329825357
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0355
CAS号: 393514-24-4
MDL号: MFCD08690556
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HK$1,187.54

产品描述

一种有效的TRPV1通道拮抗剂.

Application

BCTC or (4-Tertbutylphenyl)-4-(3-chloropyridin-2-Yl) tetrahydropyrazine-1(2H)-carbox-amide has been used as transient receptor potential melastatin 8 (TRPM8) antagonist to study its effects on proliferation and cell viability.[1]

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

BCTC is a potent antagonist of the vanilloid receptor TRPV1. BCTC blocks capsaicin-induced contractions in a variety of smooth muscle tissues, including guinea pig ileum, bladder and trachea with no effects on capsaicin-sensitive, sensory neuron-mediated positive inotropy. The compound penetrates the CNS and has strong analgesic properties.

BCTC或(4-叔丁基苯基)-4-(3-氯吡啶-2--2-Yl)四氢吡嗪-1(2H)-羧酰胺已被用作瞬时受体电位褪黑素8(TRPM8)拮抗剂来研究其对增殖和细胞的影响 生存力。[1]
BCTC是类香草素受体TRPV1的有效拮抗剂。 BCTC阻止辣椒素诱导的各种平滑肌组织收缩,包括豚鼠回肠,膀胱和气管,而对辣椒素敏感的,感觉神经元介导的正性肌力无影响。 该化合物穿透CNS,具有很强的镇痛作用。

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to beige
solubility  DMSO: >10 mg/mL
storage temp.  room temp
SMILES string  CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c3ncccc3Cl)cc1
InChI  1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
InChI key  ROGUAPYLUCHQGK-UHFFFAOYSA-N


安全信息

符号 
GHS07  GHS07
信号词 Warning
危害声明 H302
危害码 (欧洲) Xn
风险声明 (欧洲) 22
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32