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BQCA,≥98% (HPLC)

别名:1-(4-甲氧基苄基)-4-氧代-1,4-二氢喹啉-3-羧酸;1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Benzyl quinolone carboxylic acid

CAS号 338747-41-4 经验分子式(希尔表示法) C18H15NO4 分子量 309.32 MDL number MFCD01315710 PubChem Substance ID 329825446 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0497
CAS号: 338747-41-4
MDL号: MFCD01315710
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¥1,274.69

产品描述

一种有效的毒蕈碱M1受体(MACHR)阳性变构调节剂。

包装

10, 50 mg in glass bottle

Biochem/physiol Actions

BQCA is a potent muscarinic M1 receptor positive allosteric modulator with selectivity for M1 over M2-M5. It potentiates M1 activity in in vitro and in vivo assays and is orally bioavailable. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. BQCA binds allosterically to M1 to enhance the binding and efficacy of ACh at the receptor. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s. M1 agonists are being studied as potential therapeutic agents to treat Alzheimer’s disease and the cognitive and negative symptoms of schizophrenia. BQCA has been shown to improve performance in cognition tasks and increase cerebral blood flow.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to beige
solubility  DMSO: 10 mg/mL (clear solution)
storage temp.  2-8°C
SMILES string  COc1ccc(CN2C=C(C(O)=O)C(=O)c3ccccc23)cc1
InChI  1S/C18H15NO4/c1-23-13-8-6-12(7-9-13)10-19-11-15(18(21)22)17(20)14-4-2-3-5-16(14)19/h2-9,11H,10H2,1H3,(H,21,22)
InChI key  BZBBTGCKPRSPGF-UHFFFAOYSA-N


安全信息

符号 
GHS07  GHS07
信号词 Warning
危害声明 H302
危害码 (欧洲) Xn
风险声明 (欧洲) 22
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16