UK-59811 hydrochloride，≥98% (HPLC)

图片 UK-59811 hydrochloride，≥98% (HPLC)
别名：UK59811盐酸盐；UK59811 hydrochloride；4-(2-溴苯基)-2-[[2-(二甲氨基)乙氧基]甲基]-1,4-二氢-6-甲基-3,5-吡啶二羧酸 3-乙基5-甲酯盐酸盐；4-(2-Bromophenyl)-2-[[2-(dimethylamino)ethoxy]methyl]-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester hydrochloride

Empirical Formula (Hill Notation): C22H29BrN2O5 · HCl 分子量: 517.84 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0353
CAS号: 102672-02-6
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说明

生化/生理作用

UK-59811 is a 1,4-dihydropyridine calcium channel blocker. It has been used in a crystallographic and functional analysis of drug binding to the bacterial homotetrameric model voltage-gated calcium channel CaVAb, comparing 1,4-dihydropyridine binding to phenylalkylamine binding. UK-59811 inhibited CaVAb with an IC50 value of 194 nM, binding at the outer, lipid-facing surface of the pore at the interface between two CaVAb subunits, while at concentrations above 1 μM, it also bound in the pore. It was contrasted with phenylalkylamine Br-verapamil which binds on the intracellular side of the selectivity filter in the central cavity of the pore, physically blocking the pore.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

manufacturer/tradename

Pfizer®

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

创始人

Pfizer

储存温度

2-8°C

SMILES string

CCOC(C1=C(COCCN(C)C)NC(C)=C(C(OC)=O)C1C2=C(Br)C=CC=C2)=O

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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