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ILS-920,≥98% (HPLC)

ILS920;Empirical Formula (Hill Notation): C57H86N2O14 CAS号: 892494-07-4 分子量: 1023.30 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0329
CAS号: 892494-07-4
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$354.21

说明

一般描述

Synonym: (3S,6R,7E,9R,10R,12R,14S,15S,18R,19E,21S,23S,26R,27R,34aS)-3,4,9,10,13,14,15,16,18,21,22,23,24,25,26,27,32,33,34,34a-eicosahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-16-phenyl-23,27-epoxy-15,18-ethenopyrido[2,1-r][1,16,2,19]dioxadiazacyclohentriacontine-1,5,11,28,29(6H,12H,31H)-pentone
 

包装

5, 25 mg in glass bottle
 

生化/生理作用

ILS-920 is a rapamycin derivative with reduced immunosuppressive activity and enhanced neuroprotective activities including efficacy in vivo stroke model. ILS-920 predominantly binds to FKBP52 with a 972-fold higher selectivity for FKBP52 vs. FKBP12 than that of rapamycin, and also binds to the β-subunit of L-type voltage dependent Ca2+ channels. This dual functionality may contribute to the compound′s efficacy in stroke models.
 
ILS-920 是一种雷帕霉素衍生物,具有降低的免疫抑制活性和增强的神经保护活性,包括在体内中风模型中的功效。 ILS-920 主要与 FKBP52 结合,对 FKBP52 与 FKBP12 的选择性比雷帕霉素高 972 倍,并且还结合 L 型电压依赖性 Ca2+ 通道的 β-亚基。 这种双重功能可能有助于该化合物在中风模型中的功效。
 

其他说明

This compound was developed by Pfizer for Immunology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

运输

dry ice

储存温度

−20°C

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16