sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

PF-04455242 hydrochloride,≥98% (HPLC)

别名:N-(2-Methylpropyl)-2′-(1-pyrrolidinylsulfonyl)-1,1′-biphenyl-4-methanamine hydrochloride, PF-4455242 hydrochloride, 2-Methyl-N-((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine hydrochloride

Empirical Formula (Hill Notation): C21H28N2O2S · HCl CAS号: 1322001-35-3 分子量: 408.99 MDL编号: MFCD22666388 PubChem化学物质编号: 329823774 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0206
CAS号: 1322001-35-3
MDL号: MFCD22666388
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$367.75

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

PF-4455242 is a selective k opioid receptor (KOR) antagonist with 20-fold selectivity for kappa over mu receptors (k Ki = 3 nM, μ Ki =64 nM). PF-4455242 is orally active, has good brain penetration in rats and was able to block the effects of the kappa agonist U50488. Studies indicate that k blockade has afforded antidepressant activity in several animal models. PF-4455242 has been in phase I clinical trials for trial for bipolar depression.
 
PF-4455242 是一种选择性 k 阿片受体 (KOR) 拮抗剂,对 kappa 的选择性是 mu 受体的 20 倍(k Ki = 3 nM,μ Ki =64 nM)。 PF-4455242 具有口服活性,在大鼠中具有良好的脑渗透性,并且能够阻断 kappa 激动剂 U50488 的作用。 研究表明,k 阻滞在几种动物模型中提供了抗抑郁活性。 PF-4455242 已处于双相抑郁症的 I 期临床试验阶段。
 

特点和优势

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
 

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 5 mg/mL (clear solution, warmed)

创始人

Pfizer

储存温度

room temp

SMILES string

Cl.CC(C)CNCc1ccc(cc1)-c2ccccc2S(=O)(=O)N3CCCC3

InChI

1S/C21H28N2O2S.ClH/c1-17(2)15-22-16-18-9-11-19(12-10-18)20-7-3-4-8-21(20)26(24,25)23-13-5-6-14-23;/h3-4,7-12,17,22H,5-6,13-16H2,1-2H3;1H

InChI key

WRNZYMZEVIVCFL-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16