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3-AP,≥98% (HPLC)

别名:[(3-氨基吡啶-2-基)亚甲基氨基]硫脲;3-Aminopyridine-2-carboxaldehyde thiosemicarbazone, 3-AP, PAN-811

CAS号 143621-35-6 经验分子式(希尔表示法) C7H9N5S 分子量 195.24 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0568
CAS号: 143621-35-6
MDL号: MFCD00924747
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¥968.48

产品描述

一种具有抗肿瘤活性的核糖核苷酸还原酶抑制剂和铁螯合剂。

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a ribonucleotide reductase inhibitor and iron chelator with anti-tumor activity.

3-aminopyridine carboxaldehyde thiosemicarbazone (3-AP) has a IC50 value of 0.3μM.[8] It exhibits anti-proliferative activity in preclinical models of cancer, such as lung cancer.[1] It also has an ability to increase the cytotoxicity, intracellular uptake and DNA incorporation of gemcitabine in vitro.[1]

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to light brown
solubility  DMSO: 10 meq/mL, clear
storage temp.  2-8°C
InChI  1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)/b11-4+
InChI key  XMYKNCNAZKMVQN-NYYWCZLTSA-N


安全信息

符号 
GHS06  GHS06
信号词 Danger
靶器官 Respiratory system
危害码 (欧洲) Xn
风险声明 (欧洲) 22-36/37/38
安全声明 (欧洲) 26
RIDADR UN 2811 6.1 / PGIII
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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