CPI203，≥98% (HPLC)

图片 CPI203，≥98% (HPLC)
别名：TEN010；JQ2；RG-6146；(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide；(S)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩[3,2-f][1,2,4]三唑[4,3-a][1,4]二氮杂-6-基)乙酰胺

Empirical Formula (Hill Notation): C19H18ClN5OS CAS号: 1446144-04-2 分子量: 399.90 MDL编号: MFCD27997886 PubChem化学物质编号: 329825722 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML1212
CAS号: 1446144-04-2
MDL号: MFCD27997886
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说明

生化/生理作用

CPI203 is an analog of the BET inhibitor (BETi) (+)-JQ1 and is bioavailable via oral or intraperitoneal administration.[1] It plays an important role in lenalidomide and dexamethasone functions in in vitro and in vivo models of multiple myeloma.[1] CPI203 inhibits proliferation, apoptosis and cell cycle arrest in A431 cell line and primary skin squamous cell carcinoma (SCC) cells.[2]
CPI203 is an inhibitor of BRD4, a bromodomain-containing protein that binds to histones to regulate recruitment of transcription factors. BRD4 is also an RNA Pol II kinase. CPI203 blocks BRD4 kinase activity in cells and in vivo. It has shown synergistic antitumor activity with lenalidomide in bortezomib-resistant mantle cell lymphoma.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

2-8°C

SMILES string

CC1=NN=C2[C@H](CC(N)=O)N=C(C3=CC=C(Cl)C=C3)C4=C(SC(C)=C4C)N21

InChI

1S/C19H18ClN5OS/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)22-14(8-15(21)26)18-24-23-11(3)25(18)19/h4-7,14H,8H2,1-3H3,(H2,21,26)/t14-/m0/s1

InChI key

QECMENZMDBOLDR-AWEZNQCLSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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