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KNK437,≥98% (HPLC)

别名:3-(1,3-苯并二恶唑-5-基亚甲基)-2-氧-1-吡咯烷甲醛;3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde

CAS号 218924-25-5 经验分子式(希尔表示法) C13H11NO4 分子量 245.23 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0964
CAS号: 218924-25-5
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¥1,215.34

产品描述

Application

KNK437 has been used:
• as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cells[1]
• as an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cells[2]
• as a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release[3]

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

KNK437 抑制热激蛋白(包括 hsp -27、-40、-70、-72 和 -105)的积累。 KNK437 比槲皮素更有效地抑制细胞的耐热性。

KNK437 is a benzylidene lactam compound.[4]

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to beige
solubility  DMSO: 5 mg/mL, clear (warmed)
storage temp.  room temp


安全信息

RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32