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UNC1215,≥98% (HPLC)

别名:[2-Phenylamino-4-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-phenyl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

Empirical Formula (Hill Notation): C32H43N5O2 CAS号: 1415800-43-9 分子量: 529.72 MDL编号: MFCD22683289 PubChem化学物质编号: 329825577 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0662
CAS号: 1415800-43-9
MDL号: MFCD22683289
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€152.55

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity. Lethal (3) malignant brain tumor-like protein 3 (L3MBTL3) is a putative polycomb group (PcG) protein with gene-repressing activity, a member of the MBT family of methyllysine binders. Methyl-lysine binding proteins are a family of proteins that are important epigenetic regulators that “read” the post-translational methylation state of histone lysine residues and modulate protein-protein interactions that regulate gene expression. UNC1215 has an IC50 of 20 nM and > 100-fold selectivity over 13 HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC1215 showed a significant decrease in FRAP recovery (Fluorescence Recovery After Photobleaching) time below 1 microM in cells using GFP-L3MBTL3. For full characterization details, please visit the UNC1215 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit
 
UNC1215 是一种有效的、选择性的 L3MBTL3 拮抗剂,具有细胞活性。 致死 (3) 恶性脑肿瘤样蛋白 3 (L3MBTL3) 是一种推定的多梳组 (PcG) 蛋白,具有基因抑制活性,是甲基赖氨酸结合剂 MBT 家族的成员。 甲基赖氨酸结合蛋白是一个蛋白质家族,它们是重要的表观遗传调节因子,可“读取”组蛋白赖氨酸残基的翻译后甲基化状态并调节调节基因表达的蛋白质-蛋白质相互作用。 UNC1215 的 IC50 为 20 nM,对 13 个 HMT 和激酶、离子通道、7TM 和其他表观遗传蛋白的选定代表具有 > 100 倍的选择性。 UNC1215 在使用 GFP-L3MBTL3 的细胞中显示出低于 1 microM 的 FRAP 恢复(光漂白后的荧光恢复)时间显着减少。
 

特点和优势

UNC1215 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC
 

其他说明

UNC1215 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the UNC1215 probe summary on the Chemical Probes Portal website.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear

储存温度

2-8°C

SMILES string

O=C(N1CCC(N2CCCC2)CC1)C3=CC(NC4=CC=CC=C4)=C(C(N5CCC(N6CCCC6)CC5)=O)C=C3

InChI

1S/C32H43N5O2/c38-31(36-20-12-27(13-21-36)34-16-4-5-17-34)25-10-11-29(30(24-25)33-26-8-2-1-3-9-26)32(39)37-22-14-28(15-23-37)35-18-6-7-19-35/h1-3,8-11,24,27-28,33H,4-7,12-23H2

InChI key

PQOOIERVZAXHBP-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16