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CDDO甲酯,CDDO Methyl Ester;≥98% (HPLC)

别名:CDDO-Me;甲基巴多索隆;2-氰基-3,12-二氧代-油酸-1,9(11)-二烯-28-酸甲酯;2-Cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester, Bardoxolone Methyl

CAS号 218600-53-4 经验分子式(希尔表示法) C32H43NO4 分子量 505.69 MDL number MFCD11983137 PubChem Substance ID 329824977 NACRES NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SMB00376
CAS号: 218600-53-4
MDL号: MFCD11983137
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¥1,147.74

产品描述

General description

CDDO-Me 是一种合成的三萜类化合物,具有抗炎、抗肿瘤和细胞保护作用。[2]它来源于天然产物齐墩果酸。[1]

Application

CDDO 甲酯已被用作核因子-红细胞-2 相关因子 2(NRF2)激动剂。[1]

包装

10 mg in glass bottle

100 mg in poly bottle

Biochem/physiol Actions

CDDO-Me inhibits inflammatory mediators including interleukin-6 (IL-6), IL-10, and IL-12. It enhances apoptosis induced by TNF and chemotherapeutic agents.[3] CDDO-Me exhibits anti-proliferative activity in osteosarcoma cells and enhances the effectiveness of chemotherapeutic agents by inducing an intrinsic mitochondrial-dependent apoptotic pathway. It can be used as an adjuvant treatment for advanced and fatal form of prostate cancer.[3]

性质

Quality Level  200
assay  ≥98% (HPLC)
form  powder
storage temp.  −20°C
SMILES string  CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
InChI  1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChI key  WPTTVJLTNAWYAO-KPOXMGGZSA-N
Gene Information  human ... IKBKB(3551), KEAP1(9817), NFE2L2(4780), PPARG(5468)


安全信息

RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16