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PF-06456384 trihydrochloride,≥98% (HPLC)

别名:PF06456384三盐酸盐;3-Cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]oxy]-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide trihydrochloride, Benzenesulfonamide, 3-cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]oxy]-N-1,2,4-thiadiazol-5-yl-, hydrochloride (1:3)

Empirical Formula (Hill Notation): C35H32F3N7O3S2 · 3HCl CAS号: 1834610-75-1 分子量: 829.18
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0386
CAS号: 1834610-75-1
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$410.11

说明

生化/生理作用

PF-06456384 is a highly potent and selective inhibitor against voltage-gated sodium channel NaV1.7 (SCN9A; IC50 = 0.01, <0.1, 75 nM against human, mouse, rat Nav1.7, respectively, by conventional patch clamp; human Nav1.7 IC50 = 0.58 nM by PatchExpress electrophysiology) with >300-fold selectivity over other human NaVs (IC50 = 3 nM/NaV1.2, 5.8 nM/NaV1.6, 75 nM/NaV1.7, 314 nM/NaV1.1, 1.45 μM/NaV1.4, 2.59 μM/NaV1.5, 6.44 μM/NaV1.3, 26 μM/NaV1.8).
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

H2O: 2 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

O=S(C(C=C1)=CC(C#N)=C1OC2=C(C3=CC(CNCCC4CCNCC4)=NC=C3)C=C(C5=CC=CC(C(F)(F)F)=C5)C=C2)(NC6=NC=NS6)=O

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16