SGC707，≥98% (HPLC)

5, 25 mg in glass bottle

 

SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 has an IC₅₀ value of 50 nM and >100-fold selectivity over other methyltransferases and non-epigenetic targets. SGC707 binds to PRMT3 with KD of 50 nM (ITC), and inhibits histone methylation in cells with an IC₅₀ value below 1 μM. For full characterization details, please visit the SGC707 probe summary on the Structural Genomics Consortium (SGC) website.

XY1 is the negative control for the active probe, SGC707. To request a sample of the negative control from the SGC,

 

SGC707 是一种有效的蛋白质精氨酸甲基转移酶 3 (PRMT3) 变构抑制剂。 SGC707 的 IC50 值为 50 nM，选择性比其他甲基转移酶和非表观遗传靶点高 100 倍以上。 SGC707 以 50 nM (ITC) 的 KD 与 PRMT3 结合，并以低于 1 μM 的 IC50 值抑制细胞中的组蛋白甲基化。

 

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SGC707 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

 

SGC707 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the SGC707 probe summary on the Chemical Probes Portal website.