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SGC707,≥98% (HPLC)

别名:1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea

Empirical Formula (Hill Notation): C16H18N4O2 分子量: 298.34 PubChem化学物质编号: 329825739 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1242
CAS号: 1687736-54-4
MDL号: MFCD28411624
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$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 has an IC50 value of 50 nM and >100-fold selectivity over other methyltransferases and non-epigenetic targets. SGC707 binds to PRMT3 with KD of 50 nM (ITC), and inhibits histone methylation in cells with an IC50 value below 1 μM. For full characterization details, please visit the SGC707 probe summary on the Structural Genomics Consortium (SGC) website.

XY1 is the negative control for the active probe, SGC707. To request a sample of the negative control from the SGC,
 
SGC707 是一种有效的蛋白质精氨酸甲基转移酶 3 (PRMT3) 变构抑制剂。 SGC707 的 IC50 值为 50 nM,选择性比其他甲基转移酶和非表观遗传靶点高 100 倍以上。 SGC707 以 50 nM (ITC) 的 KD 与 PRMT3 结合,并以低于 1 μM 的 IC50 值抑制细胞中的组蛋白甲基化。
 

特点和优势

SGC707 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
 

其他说明

SGC707 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the SGC707 probe summary on the Chemical Probes Portal website.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to light brown

溶解性

DMSO: 20 mg/mL, clear

储存温度

2-8°C

SMILES string

O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2

InChI

1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)

InChI key

DMIDPTCQPIJYFE-UHFFFAOYSA-N

 

安全信息

象形图

Corrosion

警示用语:

Danger

危险声明

RIDADR

NONH for all modes of transport

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16