SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 has an IC
50 value of 50 nM and >100-fold selectivity over other methyltransferases and non-epigenetic targets. SGC707 binds to PRMT3 with KD of 50 nM (ITC), and inhibits histone methylation in cells with an IC
50 value below 1 μM. For full characterization details, please visit the
SGC707 probe summary on the Structural Genomics Consortium (SGC) website.
XY1 is the negative control for the active probe, SGC707. To request a sample of the negative control from the SGC,
click here.
To learn about other SGC chemical probes for epigenetic targets, visit
sigma.com/sgc