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BAY571293 (Pritelivir),≥99%(HPLC)

CAS:348086-71-5;分子式:C18H18N4O3S2;分子量:402.49;别名:N-甲基-N-(4-甲基-5-氨磺酰基噻唑-2-基)-2-(4-(吡啶-2-基)苯基)乙酰胺;BAY57-1293
制造商品牌: BSZH 科学公司
货号(SKU): B6048
CAS号: 348086-71-5
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥1,164.00

产品描述

BAY571293是一种有效的helicase primase(解旋酶酶原)抑制剂;

Application

Pritelivir is a potent helicase primase inhibitor. BAY 57-1293 inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex. In various rodent models of HSV infection the antiviral activity of BAY 57-1293 in vivo was found to be superior compared to all compounds currently used to treat HSV infections. The compound shows profound antiviral activity in murine and rat lethal challenge models of disseminated herpes, in a murine zosteriform spread model of cutaneous disease, and in a murine ocular herpes model. It is active in parenteral, oral, and topical formulations。

Pritelivir是有效的解旋酶引发酶抑制剂。 BAY 57-1293通过废除病毒的primase-helicase复合物的酶促活性,在体外在纳摩尔范围内抑制1型和2型单纯疱疹病毒(HSV)的复制。 在各种HSV感染的啮齿动物模型中,发现BAY 57-1293在体内的抗病毒活性优于目前用于治疗HSV感染的所有化合物。 该化合物在弥散性疱疹的鼠类和大鼠致死性攻击模型,皮肤疾病的鼠类带状疱疹传播模型以及鼠类眼疱疹模型中显示出强大的抗病毒活性。 它对肠胃外,口服和局部用药有效。


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16