烟酸 [维生素B3]，Nicotinic acid；meets USP testing specifications, 99.0-101.0% dry basis

图片 烟酸 [维生素B3]，Nicotinic acid；meets USP testing specifications, 99.0-101.0% dry basis
别名：3-吡啶甲酸；吡啶-3-羧酸；尼亚生；尼克酸；抗癞皮病因子；抗糙皮病因子；维生素 B3；尼古丁酸；维生素PP；3-Picolinic acid；Niacin；Pellagra preventive factor；Pyridine-3-carboxylic acid；Vitamin B3

Empirical Formula (Hill Notation): C6H5NO2 CAS号: 59-67-6 分子量: 123.11 Beilstein: 109591 EC 号: 200-441-0 MDL编号: MFCD00006391 PubChem化学物质编号: 24897734 NACRES: NA.21
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: N5410
CAS号: 59-67-6
MDL号: MFCD00006391
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¥4,470.51

说明

烟酸，也称为烟酸或维生素B3，是一种水溶性维生素。烟酸由氨基酸色氨酸合成，主要存在于花生、鱼和瘦肉中。
烟酸已被用作抗氧化剂，以评估其在结肠LoVo细胞系中对阿霉素诱导的细胞毒性的保护作用。
尼古丁可调节脂质代谢，可用于治疗血脂异常。它是一种抗氧化剂，以烟酰胺腺嘌呤核苷酸的形式充当辅酶。烟酸缺乏导致脂质过氧化增强，也与克罗恩病有关。烟酸减少低密度脂蛋白（LDL）的合成，提高高密度脂蛋白水平。

一般描述

Nicotinic acid, also referred to as niacin or as vitamin B3, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.
 

应用

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.
 

生化/生理作用

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.
 
 

属性

生物来源

synthetic (organic)

质量水平

200

Agency

USP/NF
meets USP testing specifications

测定

99.0-101.0% dry basis

形式

powder

颜色

white

mp

236-239 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H319

危险分类

Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(F)

379.4 °F - closed cup

闪点(C)

193 °C - closed cup

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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