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VAS2870,≥97% (HPLC)

别名:VAS 2870;VAS-2870;1,3-苯并恶唑-2-基-3-苄基-3H- [1,2,3]三唑并[4,5-d]嘧啶-7-基硫醚, 7-(1,3-苯并恶唑-2-基硫烷基)-3-苄基-3H- [1,2,3]三唑并[4,5-d]嘧啶, 7-(2-苯并恶唑基硫)-3-(苯基甲基)-3H-1,2,3-三唑并[4,5-d]嘧啶;1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine

CAS号 722456-31-7 经验分子式(希尔表示法) C18H12N6OS 分子量 360.39 MDL number MFCD03407188 PubChem Substance ID 329825281 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0273
CAS号: 722456-31-7
MDL号: MFCD03407188
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$184.44

产品描述

一种具有细胞特异性NADPH氧化酶(NOX)抑制剂。

Application

VAS2870 has been used as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) inhibitor:
• to study the importance of NOX-derived reactive oxygen species in cytoskeletal organization, proper localization of E-cadherin and cell motility during zebrafish epiboly[1]
•  to study the function of Nox2 and Nox4 in lipopolysaccharide (LPS)-induced intestinal injury in high-fat diet (HFD) fed mice
• to reduce the reactive oxygen species level and study its influence on inhibiting the induction of trained innate immunity in monocytes

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

In addition to NOX4 inhibition, VAS2870 is also known to supress the reactive oxygen species (ROS) production in several cell types. It effectively impairs cell growth and increases apoptosis induced by transforming growth factor β (TGF-β) in liver cancer cells. Thus, inhibition of NOX enzymes by VAS2870 may be considered as a potential therapeutic strategy for liver cancer.

VAS2870 是一种细胞渗透性特异性 NADPH 氧化酶(NOX)抑制剂,可有效抑制血管平滑肌细胞(VSMC)中生长因子介导的 ROS 释放。

性质

Quality Level  100
assay  ≥97% (HPLC)
form  powder
color  white to beige
solubility  DMSO: ≥5 mg/mL
storage temp.  room temp
SMILES string  C(c1ccccc1)n2nnc3c(Sc4nc5ccccc5o4)ncnc23
InChI  1S/C18H12N6OS/c1-2-6-12(7-3-1)10-24-16-15(22-23-24)17(20-11-19-16)26-18-21-13-8-4-5-9-14(13)25-18/h1-9,11H,10H2
InChI key  HZSOKHVVANONPV-UHFFFAOYSA-N


安全信息

危害码 (欧洲) Xn
风险声明 (欧洲) 22
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16