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氯噻嗪,Chlorothiazide;thiazide diuretic, ≥98% (HPLC)

别名:6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Empirical Formula (Hill Notation): C7H6ClN3O4S2 CAS号: 58-94-6 分子量: 295.72 EC 号: 200-404-9 MDL编号: MFCD00058576 PubChem化学物质编号: 24278150 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): C4911
CAS号: 58-94-6
MDL号: MFCD00058576
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¥16,760

说明

氯噻嗪 (CTLD) 是一种噻嗪样利尿剂,具有抗高血压作用。

噻嗪类利尿剂中的第一种。 效果是节省钙和锂,但增加钠的排泄。
氯噻嗪已被用作平行人工膜渗透性测定 (PAMPA) 的参考标准。 它还被用于测试其对阻断 pendrin 活性的影响。

氯噻嗪 (CTLD) 具有磺酰胺基团,与氢氯噻嗪结构相似,但作用持续时间长。 CTLD 是一种碳酸酐酶抑制剂,比氢氯噻嗪更有效。

一般描述

Chlorothiazide (CTLD) is a thiazide-like diuretics and has antihypertensive effects.
 

应用

One of the first in the thiazide class of diuretics. The effect is sparing of calcium and lithium, but increases the excretion of sodium.
Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA). It has also been used to test its effect on blocking pendrin activity.
 

包装

50 g in glass bottle
 

生化/生理作用

Chlorothiazide (CTLD) shows structural resemblance with hydrochlorothiazide by having a sulfonamide group, but exhibits a long action duration. CTLD is an inhibitor of carbonic anhydrase and is more potent than hydrochlorothiazide.
 

特点和优势

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
 

法律信息

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
 
 

属性

生物来源

synthetic (organic)

质量水平

100

测定

≥98% (HPLC)

形式

powder

mp

> 300  °C

溶解性

DMF: 50 mg/mL, clear, colorless to very faintly yellow

储存温度

2-8°C

SMILES string

O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O

InChI

1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)

InChI key

JBMKAUGHUNFTOL-UHFFFAOYSA-N

Gene Information

human ... CA1(759), CA4(762), SLC12A3(6559)

 

安全信息

象形图

Health hazard

警示用语:

Danger

危险声明

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16