利钠肽, C型，Natriuretic Peptide, C-Type [CNP]；≥95% (HPLC)

Empirical Formula (Hill Notation): C93H157N27O28S3 CAS号: 127869-51-6 分子量: 2197.60 MDL编号: MFCD00080348 PubChem化学物质编号: 329818688

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: N8768

CAS号: 127869-51-6

MDL号: MFCD00080348

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目录规格.SKU-Variant

1mg
5mg
25mg

说明

Amino Acid Sequence

Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys [Disulfide Bridge: 6-22]

一般描述

Natriuretic Peptide, C-Type (NPPC/ CNP) is a 22 amino acid peptide encoded by NPPC gene mapped to human chromosome 2q37.1.[1] It belongs to the natriuretic peptide family.[2]

生化/生理作用

C-type natriuretic peptide is produced in the hypothalamus, anterior pituitary, and most major endocrine glands. It has potent venodilatory and coronary vasodilatory effects, but minimal effects on renal function.

Natriuretic Peptide, C-Type (NPC) plays a vital role in regulation of blood pressure and body fluid homeostasis. NPC-mediated signaling is essential for endochondral ossification.[1] NPC acts as a ligand for natriuretic peptide receptor B (NPR-B).[3] NPC interacts with receptors on vascular smooth muscle cells (VSMCs) and functions as an autocrine/paracrine endothelium-derived hormone.[3] It is also implicated in the endothelial dysfunction and regulation of adipogenesis, which has a crucial role in the development of obesity in childhood.[4] NPC has potential as a marker for obesity and bone injury induced by steroid hormones.[4][5] In vitro studies show that NPC is involved in the inhibition of smooth muscle cell proliferation, natriuresis, diuresis, vasodilation and inhibition of the renin- angiotensin system. NPC is associated with the development of myocardial infarction and heart failure. Plasma NPC levels can be used as a biomarker for the therapeutic efficacy of metoprolol on postural tachycardia syndrome (POTS) in children.[5]

属性

质量水平

200

检测方案

≥95% (HPLC)

形式

powder

组成

Peptide content, ≥65%

UniProt登记号

P23582

储存温度

−20°C

SMILES string

CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CN

InChI

1S/C93H157N27O28S3/c1-12-52(10)76-91(146)104-42-72(127)108-65(44-122)88(143)114-57(26-30-149-11)82(137)118-64(43-121)80(135)103-39-70(125)106-58(31-48(2)3)78(133)101-41-74(129)110-68(92(147)148)47-151-150-46-67(109-73(128)40-100-77(132)54(23-16-18-27-94)111-89(144)66(45-123)119-85(140)59(32-49(4)5)105-69(124)37-96)90(145)116-62(35-53-21-14-13-15-22-53)79(134)102-38-71(126)107-60(33-50(6)7)84(139)112-55(24-17-19-28-95)81(136)115-61(34-51(8)9)86(141)117-63(36-75(130)131)87(142)113-56(83(138)120-76)25-20-29-99-93(97)98/h13-15,21-22,48-52,54-68,76,121-123H,12,16-20,23-47,94-96H2,1-11H3,(H,100,132)(H,101,133)(H,102,134)(H,103,135)(H,104,146)(H,105,124)(H,106,125)(H,107,126)(H,108,127)(H,109,128)(H,110,129)(H,111,144)(H,112,139)(H,113,142)(H,114,143)(H,115,136)(H,116,145)(H,117,141)(H,118,137)(H,119,140)(H,120,138)(H,130,131)(H,147,148)(H4,97,98,99)/t52-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-/m0/s1

InChI key

UHSBKBYWHCBDCJ-DYGWFTAGSA-N

Gene Information

human ... NPPC(4880)

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格

属性名称	属性值
储存温度 Storage temp.	-20°C低温冷冻
全球实时库存 Availability √	美国St. Louis ≥ 50 \| 欧洲Eur. ≥ 12 \| 東京Tokyo ≥ 20 \| 香港与北京 ≥ 50

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