小鼠IgG3-κ,IgG3-Kappa from murine myeloma;clone DX, purified immunoglobulin, buffered aqueous solution

Mouse IgG3-κ;IgG3-κ来源于小鼠骨髓瘤; MDL number MFCD00164803 NACRES NA.46
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): I3784
MDL号: MFCD00164803
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IgG抗体亚型是免疫系统中最丰富的血清免疫球蛋白。 它由B细胞分泌,存在于血液和细胞外液中,可防止细菌,真菌和病毒引起的感染。 母体IgG通过胎盘转移到胎儿,这对新生儿抵抗感染的免疫防御至关重要。 IgG3具有独特的延伸铰链区,赋予更大的灵活性来自鼠类骨髓瘤的IgG3,κ特异性识别小鼠IgG3。 小鼠IgG3,κ的特异性通过免疫扩散和IEP技术确定。 纯化的骨髓瘤制剂与小鼠IgA,IgM,IgD,IgG1,IgG2a和IgG2b的抗血清无反应。

鼠骨髓瘤中的IgG3,κ用作阻断剂,用于幼虫和成虫多球棘球虫蠕虫的免疫荧光标记。 在研究抗体与脑膜炎球菌表面结合的实验中,它被用作阴性对照。

General description

IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections.[2] IgG3 is the has a unique extended hinge region conferring greater flexibility
IgG3, κ from murine myeloma specifically recognizes mouse IgG3. Specificity of the mouse IgG3, κ is determined by immunodiffusion and IEP techniques. The purified myeloma preparation is non-reactive with antisera to mouse IgA, IgM, IgD, IgG1, IgG2a and IgG2b.


IgG3, κ from murine myeloma was used as blocking agent in immunofluorescence labeling of larval and adult Echinococcus multilocularis worms.[1] It was used as negative control in assay to study the surface binding of antibodies to meningococci.[3]

Physical form

Solution in Tris buffered saline, pH 7.2, containing 0.1% sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


Quality Level200
biological sourcemouse
antibody formpurified immunoglobulin
cloneDX, monoclonal
assay≥95% (microfluidic capillary gel electrophoresis)
formbuffered aqueous solution
shipped indry ice
storage temp.−20°C


GHS07  GHS07
信号词 Warning
危害声明 H315 - H319
警示性声明 P305 + P351 + P338
危害码 (欧洲) Xn
风险声明 (欧洲) 21/22
安全声明 (欧洲) 36/37
RIDADR NONH for all modes of transport
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16