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氨基-PEG4-叔丁酯,Amino-PEG4-t-butyl ester;liquid

别名:1-氨基-3,6,9,12-四氧杂十五烷-15-酸叔丁酯;tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, H2N-PEG4-CH2CH2COOtBu, H2N-dPEG(4)-CO-OtBu

Empirical Formula (Hill Notation): C15H31NO6 CAS号: 581065-95-4 分子量: 321.41 MDL编号: MFCD11041116
制造商品牌: Sigma-Aldrich
货号(SKU): 902535
CAS号: 581065-95-4
MDL号: MFCD11041116
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¥1,423.03

说明

应用

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
 

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
 
 

属性

形式

liquid

reaction suitability

reagent type: cross-linking reagent

折射率

n/D 1.4508

密度

1.04479 g/mL

官能团

amine
ester

储存温度

−20°C

SMILES string

NCCOCCOCCOCCOCCC(OC(C)(C)C)=O

InChI

1S/C15H31NO6/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h4-13,16H2,1-3H3

InChI key

PKESARRNSGIDRD-UHFFFAOYSA-N

 

安全信息

储存分类代码

10 - Combustible liquids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 60 | 欧洲Eur. ≥ 21 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 10