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WYE-125132 [WYE-132],≥97% (HPLC)

别名:WYE125132, N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N′-methyl-urea

Empirical Formula (Hill Notation): C27H33N7O4 CAS号: 1144068-46-1 分子量: 519.60
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0321
CAS号: 1144068-46-1
MDL号: MFCD22420813
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$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

WYE-125132 (WYE-132) is a highly potent, ATP-competitive, and specific inhibitor of mTOR with an IC50 value of 0.19 nM. Unlike rapamycin, which ihibits mTOR through allosteric binding to mTOR complex 1 (mTORC1) only, WYE-132 inhibits both mTORC1 and mTORC2. WYE-125132 is >5000-fold selective for mTOR vs. phosphoinositide 3-kinase (PI3K). WYE-132 induced apoptosis in a variety of cancer lines including LNCap prostate cells and H1975 lung cancer cells. WYE-132 also inhibited ovarian cancer cell growth.
 
WYE-125132 (WYE-132) 是一种高效、ATP 竞争性的 mTOR 特异性抑制剂,IC50 值为 0.19 nM。 与仅通过与 mTOR 复合物 1 (mTORC1) 的变构结合抑制 mTOR 的雷帕霉素不同,WYE-132 抑制 mTORC1 和 mTORC2。 WYE-125132 对 mTOR 的选择性比磷酸肌醇 3-激酶 (PI3K) 高 5000 倍以上。 WYE-132 在多种癌细胞系中诱导细胞凋亡,包括 LNCap 前列腺细胞和 H1975 肺癌细胞。 WYE-132 还抑制卵巢癌细胞的生长。
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥97% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

储存温度

−20°C

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16