sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

TP-472,≥98% (HPLC)

别名:3-(6-乙酰基-吡咯并[1,2-a]嘧啶-8-基)-N-环丙基-4-甲基-苯甲酰胺;3-(6-Acetyl-pyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methyl-benzamide;TP472

Empirical Formula (Hill Notation): C20H19N3O2 分子量: 333.38 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1862
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$502.36

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

TP-472 is a selective probe for bromodomain-containing proteins BRD9 and BRD7. This BRD9/7 probe was developed out of a collaborative effort by Takeda and the SGC, and is of a different chemotype from BRD9/7 probes previously available. TP-472 has a KD value of 33nM for BRD9 and 340nM for BRD7 by ITC. It is >30 fold selective for BRD9 over all other bromodomain family members except BRD7. It is suitable for in vivo applications. For full characterization details, please visit the TP-472 probe summary on the Structural Genomics Consortium (SGC) website.

TP-472N is used as a negative control and is available from Sigma. To learn more about and purchase TP-472N,
TP-472 是含溴结构域蛋白 BRD9 和 BRD7 的选择性探针。 该 BRD9/7 探针由武田和 SGC 合作开发,与之前可用的 BRD9/7 探针具有不同的化学型。 TP-472 的 BRD9 的 KD 值为 33nM,ITC 的 BRD7 的 KD 值为 340nM。 它对 BRD9 的选择性是除 BRD7 以外的所有其他溴结构域家族成员的 30 倍以上。
 

特点和优势

TP-472 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

储存温度

2-8°C

SMILES string

O=C(C)C1=CC(C2=C(C)C=CC(C(NC3CC3)=O)=C2)=C4N=CC=CN41

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16