TP-472，≥98% (HPLC)

5, 25 mg in glass bottle

 

TP-472 is a selective probe for bromodomain-containing proteins BRD9 and BRD7. This BRD9/7 probe was developed out of a collaborative effort by Takeda and the SGC, and is of a different chemotype from BRD9/7 probes previously available. TP-472 has a KD value of 33nM for BRD9 and 340nM for BRD7 by ITC. It is >30 fold selective for BRD9 over all other bromodomain family members except BRD7. It is suitable for in vivo applications. For full characterization details, please visit the TP-472 probe summary on the Structural Genomics Consortium (SGC) website.

TP-472N is used as a negative control and is available from Sigma. To learn more about and purchase TP-472N,

TP-472 是含溴结构域蛋白 BRD9 和 BRD7 的选择性探针。 该 BRD9/7 探针由武田和 SGC 合作开发，与之前可用的 BRD9/7 探针具有不同的化学型。 TP-472 的 BRD9 的 KD 值为 33nM，ITC 的 BRD7 的 KD 值为 340nM。 它对 BRD9 的选择性是除 BRD7 以外的所有其他溴结构域家族成员的 30 倍以上。

 

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TP-472 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC