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SIS3,≥98% (HPLC), powder

别名:SIS-3;SIS 3;(2E)-1-(6,7-二甲氧基-3,4-二氢-1H-异喹啉-2-基)-3-(1-甲基-2-苯基-1H-吡咯并[2,3-b]吡啶吡啶-3-基)-丙烯酮盐酸盐;(2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride

CAS号 521984-48-5 经验分子式(希尔表示法) C28H27N3O3 · HCl 分子量 489.99 MDL number MFCD09265258 PubChem Substance ID 24724599 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): S0447
CAS号: 521984-48-5
MDL号: MFCD09265258
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$809.80

产品描述

Application

Sugar insensitive 3 (SIS3) has been used as smad3 inhibitor in various cells.[2][3][4]

包装

5 mg in glass bottle

Biochem/physiol Actions

Sugar insensitive 3 (SIS3) promotes drug-induced apoptosis and hinders the function of adenosine triphosphate (ATP)-binding cassette (ABC) transporter (ABCB1) and ABCG2. It resensitizes ABCB1 and ABCG2 overexpressed in cancerous cells, which contributes to chemotherapeutics.[1]

SIS3 是一种 TGF-β1/ALK-5磷酸化 Smad3 的新型特异性抑制剂

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  yellow
solubility  H2O: <2 mg/mL
 DMSO: >20 mg/mL
storage temp.  2-8°C
SMILES string  Cl.COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c3c(-c4ccccc4)n(C)c5ncccc35
InChI  1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
InChI key  CDKIEBFIMCSCBB-CALJPSDSSA-N


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16