RN-18，N-(2-methoxyphenyl)-2-[(4-nitrophenyl)thio]-benzamide；≥99% (HPLC)

Application

RN-18 is an HIV-1 Vif inhibitor. RN-18 antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation. RN-18 enhances Vif degradation only in the presence of A3G, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome.

RN-18是HIV-1 Vif抑制剂。 RN-18只能在A3G存在时拮抗Vif功能并抑制HIV-1复制。 RN-18以Vif依赖性方式增加细胞A3G水平，并增加A3G掺入病毒粒子而不会抑制一般蛋白酶体介导的蛋白质降解。 RN-18仅在存在A3G的情况下才增强Vif降解，通过增加A3G在病毒粒子中的掺入来降低病毒的感染性，并增强病毒基因组的胞苷脱氨作用。

安全信息