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PF-06465469,≥97% (HPLC)

别名:PF06465469;3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide

Empirical Formula (Hill Notation): C30H33N7O2 CAS号: 1407966-77-1 分子量: 523.63 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0209
CAS号: 1407966-77-1
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$362.61

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

PF-06465469 is a potent, covalent inhibitor of the nonreceptor tyrosine kinase Itk (IL-2 inducible T-cell kinase), which is expressed primarily in immune cells, and is strongly upregulated following activation of T-cells. PF-06465469 inhibits Itk enzymatic activity with an IC50 of 2 nM. The compound blocks anti-CD3 induced phosphorylation of PLCg in Jurkat cells (IC50 = 31 nM) and IL-2 production in anti-CD3 stimulated human whole blood (IC50 = 48 nM).
 
PF-06465469 是非受体酪氨酸激酶 Itk(IL-2 诱导型 T 细胞激酶)的有效共价抑制剂,其主要在免疫细胞中表达,并在 T 细胞活化后强烈上调。 PF-06465469 抑制 Itk 酶活性,IC50 为 2 nM。 该化合物可阻断 Jurkat 细胞中抗 CD3 诱导的 PLCg 磷酸化 (IC50 = 31 nM) 和抗 CD3 刺激的人全血中的 IL-2 产生 (IC50 = 48 nM)。
 

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥97% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear

创始人

Pfizer

储存温度

2-8°C

 

安全信息

象形图

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警示用语:

Warning

危险声明

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16