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RANTES human,[CCL5, SIS-δ, TCP228];≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Regulated on Activation, Normal T-cell Expressed and Secreted;EINECS 编号 200-835-2 MDL number MFCD00213042 NACRES NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): R6267
MDL号: MFCD00213042
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¥3,444.04

产品描述

General description

Regulated on activation, normal T cell expressed and secreted (RANTES), also known as C-C motif chemokine ligand 5 (CCL5), is encoded by the gene mapped to human chromosome 17.[1] RANTES belongs to the chemokine family of proinflammatory basic polypeptides and is expressed by various hematopoietic and non-hematopoietic cell types involved in homing and migration of effector and memory T cells during acute infections.[2][4]

Biochem/physiol Actions

Regulated on activation, normal T cell expressed and secreted (RANTES) is a chemoattractant towards monocytes, dendritic cells (DCs), memory T cells (CD4+/CD45RO), basophils, and eosinophils. The encoded chemokine protein functions as a ligand for CCR1, CCR3, and CCR5.[1][4] RANTES inhibits the action of R5 strains of HIV-1 via blocking CCR5 receptor. A variant of RANTES gene is linked with susceptibility to HIV-1 infection and disease progression. Hence, this can be used as a potent biomarker to determine the prognosis of HIV -1 infection.[1][3]

Physical form

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.

Analysis Note

The biological activity is tested in culture using Baf/3 cells. Chemotaxis: EC50: 1-5 ng/mL

性质

Quality Level  100
biological source  human
recombinant  expressed in E. coli
assay  ≥97% (SDS-PAGE)
form  lyophilized powder
potency  1-5 ng/mL EC50
mol wt  7.8-8.7 kDa
packaging  pkg of 10 μg
storage condition  avoid repeated freeze/thaw cycles
application(s)  cell culture | mammalian: suitable
impurities  endotoxin, tested
UniProt accession no.  P13501
storage temp.  −20°C
Gene Information  human ... CCL5(6352)


安全信息

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 60 | 欧洲Eur. ≥ 21 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 10