PF4800567盐酸盐，PF-4800567 hydrochloride；≥98% (HPLC)

图片 PF4800567盐酸盐，PF-4800567 hydrochloride；≥98% (HPLC)
别名：PF4800567 HCl；3-[(3-氯苯氧基)甲基]-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-d]嘧啶-4-胺盐酸盐；3-(3-Chlorophenoxy)methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo3,4-dpyrimidin-4-amine hydrochloride, PF 4800567

Empirical Formula (Hill Notation): C17H18ClN5O2 · HCl CAS号: 1391052-28-0 分子量: 396.27
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0328
CAS号: 1391052-28-0
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¥1,591.58

说明

生化/生理作用

PF-4800567 is a casein kinase 1e (CK1e) selective inhibitor (IC50 = 32 nM) that is 20 fold selective for the CK1e isoform over CK1d. PF-4800567 blockes CK1e-mediated PER3 nuclear translocation, but does not effect the circadian clock in animal studies.
PF-4800567 is also known as (3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride).[1] It can block the epidermal growth factor receptor (EGFR) at micromolar concentrations. PF-4800567 helps to improve the locomotor stimulant reaction to methamphetamine (MA) and fentanyl.[2]
 

其他说明

PF-4800567 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PF-4800567 probe summary on the Chemical Probes Portal website.
This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

创始人

Pfizer

运输

dry ice

储存温度

−20°C

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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