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钛-2133,GGTI-2133;≥98% (HPLC), solid

别名:N-[[4-(咪唑-4-基)甲基氨基] -2-(1-萘基)苯甲酰基]亮氨酸三氟乙酸盐;GGTI2133;钛2133; [191102-79-1];N-[[4-(Imidazol-4-yl)methylamino]-2-(1-naphthyl)benzoyl]leucine trifluoroacetate salt

Empirical Formula (Hill Notation): C27H28N4O3 · C2HF3O2 CAS号: 1217480-14-2 分子量: 570.56 MDL编号: MFCD07776925 PubChem化学物质编号: 24724491 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): G5294
CAS号: 1217480-14-2
MDL号: MFCD07776925
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¥2,244.34

说明

应用

GGTI-2133 has been used
  • To understand the role of geranylgeranyl transferase in the regulation of CXC chemokine production and neutrophil recruitment in the lung.[1]
  • To study the importance of geranylgeranylation in cell adhesion.[2]
  • To measure ligand-induced ADP-ribosylation factor 6 (Arf6) activation in breast cancer cells.[3]

生化/生理作用

GGTI-2133 is a cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I; IC50 = 38 nM) with a 140-fold selectivity over farnesyltransferase (FTase; IC50 = 5.4 μM).
GGTase I mediates prenylation to induce the oncogenic functions of the Ras and Rho proteins. Thus, GGTase I inhibitors can be utilized as effective anticancer drugs.[4] They are also useful in treating inflammation, atherosclerosis, multiple sclerosis and other diseases.[5]
 
 

属性

质量水平

测定

≥98% (HPLC)

形式

solid

颜色

white to beige

mp

103-118.5 °C

溶解性

DMSO: 25 mg/mL
H2O: insoluble

储存温度

−20°C

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)c1ccc(NCc2c[nH]cn2)cc1-c3cccc4ccccc34)C(O)=O

InChI

1S/C27H28N4O3.C2HF3O2/c1-17(2)12-25(27(33)34)31-26(32)23-11-10-19(29-15-20-14-28-16-30-20)13-24(23)22-9-5-7-18-6-3-4-8-21(18)22;3-2(4,5)1(6)7/h3-11,13-14,16-17,25,29H,12,15H2,1-2H3,(H,28,30)(H,31,32)(H,33,34);(H,6,7)/t25-;/m0./s1

InChI key

FXXUNOYBYJFSRB-UQIIZPHYSA-N

Gene Information

human ... FNTA(2339) , PGGT1B(5229)

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32