PF-06250112，≥98% (HPLC)

PF-06250112 is a potent inhibitor of Bruton′s tyrosine kinase (BTK). PF-06250112 blocks both B-cell receptor and FcR-mediated signaling, and prevents FcR-dependent, Antibody-mediated proteinuria in a mouse glomerulonephritis model.

 

PF-06250112 是一种有效的布鲁顿酪氨酸激酶 (BTK) 抑制剂。 PF-06250112 在小鼠肾小球肾炎模型中阻断 B 细胞受体和 FcR 介导的信号传导，并防止 FcR 依赖性抗体介导的蛋白尿。

 

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