PF-05089771，≥98% (HPLC)

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别名：4-2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy-5-chloro-2-fluoro-N-4-thiazolyl-benzenesulfonamide 4-methylbenzenesulfonate (1:1), 4-2-(5-Amino-1H-pyrazol-4-yl)-4-chloro-phenoxy-5-chloro-2-fluoro-N-thiazol-4-yl-benzenesulfonamide p-toluene sulfonate salt, PF-05089771 p-toluene sulfonate salt

Empirical Formula (Hill Notation): C18H12Cl2FN5O3S2 · C7H8O3S CAS号: 1430806-04-4 分子量: 672.56 PubChem化学物质编号: 329823831

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: PZ0311

CAS号: 1430806-04-4

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目录价.SKU-Variant

5mg
25mg [+$708.78]

$354.21

数量:

说明

包装

5, 25 mg in glass bottle

生化/生理作用

PF-05089771 is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1.7 with an IC₅₀ value of 11 nM. PF-05089771 targets the voltage-sensing domain, preferentially interacting with, and stabilizing, inactivated channel conformations by interaction with the voltage-sensor domain (VSD) of Domain 4. Nav1.7 is expressed in sensory neurons and is critical for pain processing. PF-05089771 is being investigated for the treatment of chronic neuropathic pain.

其他说明

This compound was developed by Pfizer for Ion Channel research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

法律信息

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer^®

颜色

white to beige

溶解性

DMSO: 30 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

ClC1=CC(C2=C(N)NN=C2)=C(OC3=C(Cl)C=C(S(NC4=CSC=N4)(=O)=O)C(F)=C3)C=C1.CC5=CC=C(S(=O)(O)=O)C=C5

InChI

1S/C18H12Cl2FN5O3S2.C7H8O3S/c19-9-1-2-14(10(3-9)11-6-24-25-18(11)22)29-15-5-13(21)16(4-12(15)20)31(27,28)26-17-7-30-8-23-17;1-6-2-4-7(5-3-6)11(8,9)10/h1-8,26H,(H3,22,24,25);2-5H,1H3,(H,8,9,10)

InChI key

NVKBPDYKPNYMDR-UHFFFAOYSA-N

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	常温阴凉避光
全球实时库存 Availability √	美国St. Louis ≥ 33 \| 欧洲Eur. ≥ 27 \| 東京Tokyo ≥ 9 \| 香港与北京 ≥ 16