PF-05089771，≥98% (HPLC)

图片 PF-05089771，≥98% (HPLC)
别名：4-[2-(3-氨基-1H-吡唑-4-基)-4-氯苯氧基]-5-氯-2-氟-N-4-噻唑基苯磺酰胺 4-甲基苯磺酸酯； 4-[2-(5-氨基-1H-吡唑-4-基)-4-氯苯氧基]-5-氯-2-氟-N-噻唑-4-基苯磺酰胺对甲苯磺酸盐；4-2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy-5-chloro-2-fluoro-N-4-thiazolyl-benzenesulfonamide 4-methylbenzenesulfonate (1:1), 4-2-(5-Amino-1H-pyrazol-4-yl)-4-chloro-phenoxy-5-chloro-2-fluoro-N-thiazol-4-yl-benzenesulfonamide p-toluene sulfonate salt, PF-05089771 p-toluene sulfonate salt

Empirical Formula (Hill Notation): C18H12Cl2FN5O3S2 · C7H8O3S CAS号: 1430806-04-4 分子量: 672.56 PubChem化学物质编号: 329823831
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0311
CAS号: 1430806-04-4
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¥1,764.05

说明

生化/生理作用

PF-05089771 is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1.7 with an IC50 value of 11 nM. PF-05089771 targets the voltage-sensing domain, preferentially interacting with, and stabilizing, inactivated channel conformations by interaction with the voltage-sensor domain (VSD) of Domain 4. Nav1.7 is expressed in sensory neurons and is critical for pain processing. PF-05089771 is being investigated for the treatment of chronic neuropathic pain.
 

其他说明

This compound was developed by Pfizer for Ion Channel research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

manufacturer/tradename

Pfizer®

颜色

white to beige

溶解性

DMSO: 30 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

ClC1=CC(C2=C(N)NN=C2)=C(OC3=C(Cl)C=C(S(NC4=CSC=N4)(=O)=O)C(F)=C3)C=C1.CC5=CC=C(S(=O)(O)=O)C=C5

InChI

1S/C18H12Cl2FN5O3S2.C7H8O3S/c19-9-1-2-14(10(3-9)11-6-24-25-18(11)22)29-15-5-13(21)16(4-12(15)20)31(27,28)26-17-7-30-8-23-17;1-6-2-4-7(5-3-6)11(8,9)10/h1-8,26H,(H3,22,24,25);2-5H,1H3,(H,8,9,10)

InChI key

NVKBPDYKPNYMDR-UHFFFAOYSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
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