PF-04937319，≥98% (HPLC)

图片 PF-04937319，≥98% (HPLC)
别名：PF04937319；N,N-二甲基-5-(2-甲基-6-((5-甲基吡嗪-2-基)氨基甲酰基)苯并呋喃-4-基)氧基)嘧啶-2-甲酰胺；N,N-二甲基-5-[[2-甲基-6-[[（5-甲基-2-吡嗪基）氨基]羰基]-4-苯并呋喃基]氧基]-2-嘧啶甲酰胺；N,N-Dimethyl-5-[[2-methyl-6-[[(5-methyl-2-pyrazinyl)amino]carbonyl]-4-benzofuranyl]oxy]-2-pyrimidinecarboxamide, N, N-Dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide

Empirical Formula (Hill Notation): C22H20N6O4 CAS号: 1245603-92-2 分子量: 432.43 MDL编号: MFCD26960571 PubChem化学物质编号: 329823838 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0320
CAS号: 1245603-92-2
MDL号: MFCD26960571
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¥1,591.58

说明

一般描述

PF-04937319 is a partial activator of glycokinase (GK) enzyme.[1][2][3]
 

生化/生理作用

PF-04937319 is a glucokinase activator with an EC50 value of 174 nM. PF-04937319 was found to improve glycemic control in adults with type 2 diabetes when used in conjunction with metformin.
PF-04937319, unlike other glucokinase activators, is capable of maintaining lower-glucose levels without it resulting in hypoglycemia. In type II diabetic patients where metformin treatment is inadequate, PF-04937319 is capable of maintaining glycemic control within the acceptable risk-benefit profile.[1]
 

其他说明

This compound was developed by Pfizer for Cytokines & Growth Factors research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

CC(O1)=CC2=C1C=C(C(NC3=NC=C(C)N=C3)=O)C=C2OC4=CN=C(C(N(C)C)=O)N=C4

InChI

1S/C22H20N6O4/c1-12-8-24-19(11-23-12)27-21(29)14-6-17-16(5-13(2)31-17)18(7-14)32-15-9-25-20(26-10-15)22(30)28(3)4/h5-11H,1-4H3,(H,24,27,29)

InChI key

MASKQITXHVYVFL-UHFFFAOYSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

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