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MabSelect Xtra抗体纯化层析树脂，MabSelect Xtra antibody purification chromatography resin

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MabSelect Xtra具有超高动态结合能力，是一种蛋白质A树脂，旨在满足单克隆抗体原料中表达水平不断提高的需求。17526902；17526904；17526906；17526907；17526905；17526903

制造商品牌: (安)法玛西亚 Amersham Pharmacia , GE 生命科学 [思拓凡 Cytiva]

货号（SKU）: 17526903

增值税发票 √ 免费送货 √ 订货电话：010-68689484

目录价.SKU-Variant

25mL
200mL [+$7,967.40]
1L [+$30,555.21]

$7,052.99

数量:

MabSelect Xtra antibody purification chromatography resin 抗体纯化层析树脂

MabSelect Xtra, with extra high dynamic binding capacity, is a protein A resin developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks.

比目前可用的蛋白 A 层析树脂具有更高的动态结合能力。
通过降低原材料成本和/或减少循环次数来提高工艺经济性。
由于高配体选择性和基质亲水性，高纯度捕获。
与 MabSelect SuRe 和 MabSelect 相比，压力/流动特性略低。
Resin 满足工业对供应安全性、强大性能和监管支持的需求。
孔隙率增加
MabSelect Xtra 具有与 MabSelect 相同的重组蛋白 A 配体，但基于高流动性琼脂糖基质，与 MabSelect 相比，具有更高的孔隙率和略微减小的粒径。这导致更高的容量——MabSelect Xtra 对 IgG 的动态结合容量比目前可用的蛋白 A 层析树脂高约 30%。

此外，MabSelect Xtra 对许多 Fc 融合蛋白具有更高的容量。

降低成本
与其他蛋白 A 树脂相比，MabSelect Xtra 树脂的总体生产成本较低，因为它可以以更少的批次处理浓缩原料。

Higher dynamic binding capacity than currently available Protein A chromatography resins.
Improved process economics through reduced raw materials costs and/or reduced number of cycles.
High purity capture due to high ligand selectivity and matrix hydrophilicity.
Slightly lower pressure/flow properties compared to MabSelect SuRe and MabSelect.
Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.

Increased porosity

MabSelect Xtra has the same recombinant Protein A ligand as MabSelect but is based on a high-flow agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography resins.

In addition, MabSelect Xtra has a higher capacity for many Fc-fusion proteins.

Lower costs

Compared with he other protein A resins, MabSelect Xtra resin provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.

Prepacked columns and other formats

MabSelect Xtra is available in the following formats:

Process development scale – prepacked

PreDictor MabSelect Xtra filter plates – 96-well plates for high-throughput screening or process development.
PreDictor RoboColumn MabSelect Xtra – minitiaturized column format for high throughput process development
HiScreen MabSelect Xtra columns – optimized for method and process development.

Lab/research scale – prepacked for manual purification

HiTrap MabSelect Xtra columns – for easy use with a syringe, peristaltic pump, or chromatography system.

Lab/research scale – prepacked for automated purification and analysis

HiTrap MabSelect Xtra columns – for easy use with a syringe, peristaltic pump, or chromatography system.

Learn about prepacked HiScreen MabSelect Xtra, HiTrap MabSelect Xtra, ReadyToProcess MabSelect Xtra columns, PreDictor MabSelect Xtra or PreDictor Robocolumns MabSelect Xtra

Parameter	MabSelect Xtra, 1 L
Chromatography technique	Antibody affinity chromatography
BioProcess resin	Yes
Ligand	Recombinant protein A (E.coli)
Particle size, d_50V¹	~75 µm
Matrix	Highly cross-linked agarose
Ligand Coupling Method	Epoxy activation
Binding Capacity/ml Chromatography Medium²	Approx. 40 mg humanlgG/mL at 2.4 min residence time
pH stability, operational³	3–10
pH stability, CIP⁴	2–12
Pressure/Flow Specification	< 300 cm/h, < 200 kPa, BPG 300, bed height 20 cm
Storage	2 to 8°C, 20% Ethanol
Certificate of Analysis	Yes
Pack size	1 L

¹Median particle size of the cumulative volume distribution.
²Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm.
³pH range where resin can be operated without significant change in function.
⁴pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 33 \| 欧洲Eur. ≥ 27 \| 東京Tokyo ≥ 9 \| 香港与北京 ≥ 16

MabSelect Xtra抗体纯化层析树脂，MabSelect Xtra antibody purification chromatography resin

MabSelect Xtra antibody purification chromatography resin 抗体纯化层析树脂

Increased porosity

Lower costs

Prepacked columns and other formats

Process development scale – prepacked

Lab/research scale – prepacked for manual purification

Lab/research scale – prepacked for automated purification and analysis

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