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MabSelect Xtra抗体纯化层析树脂,MabSelect Xtra antibody purification chromatography resin

MabSelect Xtra具有超高动态结合能力,是一种蛋白质A树脂,旨在满足单克隆抗体原料中表达水平不断提高的需求。17526902;17526904;17526906;17526907;17526905;17526903
货号(SKU): 17526903
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$7,052.99

MabSelect Xtra, with extra high dynamic binding capacity, is a protein A resin developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks.

比目前可用的蛋白 A 层析树脂具有更高的动态结合能力。
通过降低原材料成本和/或减少循环次数来提高工艺经济性。
由于高配体选择性和基质亲水性,高纯度捕获。
与 MabSelect SuRe 和 MabSelect 相比,压力/流动特性略低。
Resin 满足工业对供应安全性、强大性能和监管支持的需求。
孔隙率增加
MabSelect Xtra 具有与 MabSelect 相同的重组蛋白 A 配体,但基于高流动性琼脂糖基质,与 MabSelect 相比,具有更高的孔隙率和略微减小的粒径。这导致更高的容量——MabSelect Xtra 对 IgG 的动态结合容量比目前可用的蛋白 A 层析树脂高约 30%。

此外,MabSelect Xtra 对许多 Fc 融合蛋白具有更高的容量。

降低成本
与其他蛋白 A 树脂相比,MabSelect Xtra 树脂的总体生产成本较低,因为它可以以更少的批次处理浓缩原料。

  • Higher dynamic binding capacity than currently available Protein A chromatography resins.
  • Improved process economics through reduced raw materials costs and/or reduced number of cycles.
  • High purity capture due to high ligand selectivity and matrix hydrophilicity.
  • Slightly lower pressure/flow properties compared to MabSelect SuRe and MabSelect.
  • Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.

Increased porosity

MabSelect Xtra has the same recombinant Protein A ligand as MabSelect but is based on a high-flow agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography resins.

In addition, MabSelect Xtra has a higher capacity for many Fc-fusion proteins.

Lower costs

Compared with he other protein A resins, MabSelect Xtra resin provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.

Prepacked columns and other formats

MabSelect Xtra is available in the following formats: 

Process development scale – prepacked

  • PreDictor MabSelect Xtra filter plates – 96-well plates for high-throughput screening or process development.
  • PreDictor RoboColumn MabSelect Xtra – minitiaturized column format for high throughput process development
  • HiScreen MabSelect Xtra columns – optimized for method and process development.

Lab/research scale – prepacked for manual purification

HiTrap MabSelect Xtra columns – for easy use with a syringe, peristaltic pump, or chromatography system.

Lab/research scale – prepacked for automated purification and analysis

HiTrap MabSelect Xtra columns – for easy use with a syringe, peristaltic pump, or chromatography system.

Learn about prepacked HiScreen MabSelect XtraHiTrap MabSelect XtraReadyToProcess MabSelect Xtra columnsPreDictor MabSelect Xtra or PreDictor Robocolumns MabSelect Xtra

 

ParameterMabSelect Xtra, 1 L
Chromatography techniqueAntibody affinity chromatography 
BioProcess resinYes 
LigandRecombinant protein A (E.coli) 
Particle size, d50V1~75 µm 
MatrixHighly cross-linked agarose 
Ligand Coupling MethodEpoxy activation 
Binding Capacity/ml Chromatography Medium2Approx. 40 mg humanlgG/mL at 2.4 min residence time 
pH stability, operational33–10 
pH stability, CIP42–12 
Pressure/Flow Specification< 300 cm/h, < 200 kPa, BPG 300, bed height 20 cm 
Storage2 to 8°C, 20% Ethanol 
Certificate of AnalysisYes 
Pack size1 L 
  • 1Median particle size of the cumulative volume distribution.
  • 2Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm.
  • 3pH range where resin can be operated without significant change in function.
  • 4pH below 3 is sometimes required to elute strongly bound IgG species. However,  protein ligands may hydrolyze at very low pH.
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16